Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome.
Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome.
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DOI：
10.1186/s13195-014-0068-z
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Stern RA
中科院分区：
文献类型：
--
作者：
Montenigro PH;Baugh CM;Daneshvar DH;Mez J;Budson AE;Au R;Katz DI;Cantu RC;Stern RA
自世纪初以来，就已经描述了头部反复撞击的长期后果。术语，如拳醉和拳击员痴呆症首先被用来描述拳击手经历的临床综合征。一个更通用的名称，慢性创伤性脑病（CTE），自20世纪中期以来一直被使用，近年来被用来描述一种不仅在拳击手身上发现的神经退行性疾病，而且在美式足球运动员，其他接触性运动员，退伍军人和其他有重复性脑创伤史的人身上发现，包括脑震荡和亚脑震荡创伤。本文回顾了202例CTE的临床表现的文献。临床特征包括情绪障碍（例如抑郁和绝望）、行为障碍（例如爆发性和暴力）、认知障碍（例如记忆力、执行功能、注意力和痴呆），以及较不常见的运动功能障碍（例如帕金森综合征、共济失调和构音障碍）。我们提出了创伤性脑病综合征（TES）的研究标准，其中包括四个变种或亚型（TES行为/情绪变异，TES认知变异，TES混合变异，TES痴呆）以及分类的“可能CTE”和“可能CTE”。随着新的研究结果的出现，预计这些拟议标准将得到修改和更新。它们不用于临床诊断。相反，它们应被视为研究标准，可用于研究CTE和相关疾病的根本原因，风险因素，鉴别诊断，预防和治疗。
The long-term consequences of repetitive head impacts have been described since the early 20th century. Terms such as punch drunk and dementia pugilistica were first used to describe the clinical syndromes experienced by boxers. A more generic designation, chronic traumatic encephalopathy (CTE), has been employed since the mid-1900s and has been used in recent years to describe a neurodegenerative disease found not just in boxers but in American football players, other contact sport athletes, military veterans, and others with histories of repetitive brain trauma, including concussions and subconcussive trauma. This article reviews the literature of the clinical manifestations of CTE from 202 published cases. The clinical features include impairments in mood (for example, depression and hopelessness), behavior (for example, explosivity and violence), cognition (for example, impaired memory, executive functioning, attention, and dementia), and, less commonly, motor functioning (for example, parkinsonism, ataxia, and dysarthria). We present proposed research criteria for traumatic encephalopathy syndrome (TES) which consist of four variants or subtypes (TES behavioral/mood variant, TES cognitive variant, TES mixed variant, and TES dementia) as well as classifications of ‘probable CTE’ and ‘possible CTE’. These proposed criteria are expected to be modified and updated as new research findings become available. They are not meant to be used for a clinical diagnosis. Rather, they should be viewed as research criteria that can be employed in studies of the underlying causes, risk factors, differential diagnosis, prevention, and treatment of CTE and related disorders.
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影响因子：
17.1
作者：
Goldstein LE;Fisher AM;Tagge CA;Zhang XL;Velisek L;Sullivan JA;Upreti C;Kracht JM;Ericsson M;Wojnarowicz MW;Goletiani CJ;Maglakelidze GM;Casey N;Moncaster JA;Minaeva O;Moir RD;Nowinski CJ;Stern RA;Cantu RC;Geiling J;Blusztajn JK;Wolozin BL;Ikezu T;Stein TD;Budson AE;Kowall NW;Chargin D;Sharon A;Saman S;Hall GF;Moss WC;Cleveland RO;Tanzi RE;Stanton PK;McKee AC
通讯作者：
McKee AC
影响因子：
105.7
作者：
CRITCHLEY, M
通讯作者：
CRITCHLEY, M
DOI：
10.1016/j.jalz.2011.03.004
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jack CR Jr;Albert MS;Knopman DS;McKhann GM;Sperling RA;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH
影响因子：
2.9
作者：
Bigler ED
通讯作者：
Bigler ED
影响因子：
120.7
作者：
Jordan, BD;Relkin, NR;Gandy, S
通讯作者：
Gandy, S