Perihilar cholangiocarcinoma in an explanted liver after Kasai operation for biliary atresia: A case report and literature review
Perihilar cholangiocarcinoma in an explanted liver after Kasai operation for biliary atresia: A case report and literature review
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胆道闭锁葛西手术后移植肝门周胆管癌一例报告及文献复习
DOI：
10.1111/pin.13016
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发表时间：
2020
影响因子：
2.2
通讯作者：
Haga Hironori
中科院分区：
文献类型：
--
作者：
Uno Shunsuke;Kataoka Tatsuki R.;Okajima Hideaki;Taura Kojiro;Sakurai Takaki;Haga Hironori
Kasai 手术广泛用于治疗胆道闭锁（BA），因为它可以改善预后。胆道癌很少被报道为葛西手术后的并发症。一名 17 岁男性因 BA 葛西手术后出现进行性黄疸和肝功能障碍而接受肝移植。对取出的肝脏进行肉眼检查，发现在取出的肝门处有一个直径 3.6 厘米的肿块。肿瘤由胶原基质中腺细胞的非典型增殖组成。鉴别诊断包括华丽的导管反应和原发性腺癌。免疫组织化学显示，腺细胞 IGF2BP3 和 S100P 呈弥漫性阳性，但 CDX2 呈阴性。诊断为源自肝门的肝外胆管癌。据我们所知，这是BA Kasai手术后第三例肝门周围胆管癌。之前报道的病例预后较差，但目前的病例在15年的随访中并未复发。胆管癌和肝细胞癌可作为 Kasai 手术后 BA 的晚期并发症发生，早期发现和肝移植可改善预后。
Kasai operation is widely performed for biliary atresia (BA), as it improves the prognosis. Biliary tract cancer has rarely been reported as a complication after Kasai operation. A 17‐year‐old man underwent liver transplantation for progressive jaundice and liver dysfunction after Kasai operation for BA. A macroscopic examination of the explanted liver revealed a 3.6‐cm‐diameter mass in the hilus of the explanted liver. The tumor consisted of an atypical proliferation of glandular cells in the collagenous stroma. The differential diagnosis included a florid ductular reaction and primary adenocarcinoma. Immunohistochemistry revealed that the glandular cells were diffusely positive for IGF2BP3 and S100P, but negative for CDX2. A diagnosis of extrahepatic cholangiocarcinoma arising from the liver hilus was made. To our knowledge, this is the third case of perihilar cholangiocarcinoma after Kasai operation for BA. The previously reported cases had a poor prognosis, but the current case did not recur during a 15‐year follow‐up. Cholangiocarcinoma and hepatocellular carcinoma can occur as a late complication of BA after Kasai operation, and early detection and liver transplantation may improve the prognosis.
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由于先天性胆道闭锁导致胆管癌与胆汁性肝硬化相关。
DOI：
--
发表时间：
1977
期刊：
A M A Journal of Diseases of Children
影响因子：
--
作者：
P. Kulkarni;E. Beatty
通讯作者：
E. Beatty
可矫正性胆道闭锁与胆管癌：一例63岁患者的病例报告
影响因子：
0.8
作者：
M. Nio;M. Wada;H. Sasaki;Hiromu Tanaka;M. Hashimoto;Yudai Nakajima
通讯作者：
Yudai Nakajima
影响因子：
29.4
作者：
Sia, Daniela;Villanueva, Augusto;Llovet, Josep M.
通讯作者：
Llovet, Josep M.
DOI：
--
发表时间：
1972
期刊：
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
影响因子：
--
作者：
J. V. Wyk;CG Halgrimson;G. Giles;J. Lilly;G. Martineau;T. Starzl
通讯作者：
T. Starzl
胆道闭锁女孩的肝母细胞瘤：巧合还是巧合
影响因子：
3.2
作者：
F. Taat;D. Bosman;D. Aronson
通讯作者：
D. Aronson