Energy Balance and Control of Body Weight: Possible Effects of Meal Timing and Circadian Rhythm Dysregulation.
Energy Balance and Control of Body Weight: Possible Effects of Meal Timing and Circadian Rhythm Dysregulation.
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DOI：
10.3390/nu13093276
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发表时间：
2021-09-19
期刊：
影响因子：
5.9
通讯作者：
Santini F
中科院分区：
文献类型：
--
作者：
Basolo A;Bechi Genzano S;Piaggi P;Krakoff J;Santini F
能量平衡的守恒可以被认为是一个动态过程，一个成分（能量摄入或能量消耗）的变化会导致系统另一部分的生物和/或行为补偿变化。能源需求和热量摄入之间的相互作用似乎是为了在各种生活环境中保证充足的食物供应。昼夜节律通过充当人体的“计时器”，在调节许多生理功能（如睡眠、饥饿和体温）的中枢和外周时钟的控制下，在系统内稳态中起着重要作用。与生物钟相关的生物过程预期环境施加的日常需求，在理想的生理条件下同步。干扰预期需求的因素，包括常量营养素的每日分布，身体活动和光照，可能会破坏预测和实际行为之间的生理和谐。这种去脂肪化可能有利于广泛的疾病相关过程的发展，包括肥胖及其合并症。已有证据表明，24小时EE的主要成分可能会受到昼夜节律紊乱的影响。睡眠模式、进餐时间和膳食结构可以介导这些效应。增加对昼夜节律和能量平衡之间的干扰的理解可能会揭示体重增加的病理生理机制，这可能最终导致设计有效的策略来对抗肥胖症的流行。
Conservation of the energy equilibrium can be considered a dynamic process and variations of one component (energy intake or energy expenditure) cause biological and/or behavioral compensatory changes in the other part of the system. The interplay between energy demand and caloric intake appears designed to guarantee an adequate food supply in variable life contexts. The circadian rhythm plays a major role in systemic homeostasis by acting as “timekeeper” of the human body, under the control of central and peripheral clocks that regulate many physiological functions such as sleep, hunger and body temperature. Clock-associated biological processes anticipate the daily demands imposed by the environment, being synchronized under ideal physiologic conditions. Factors that interfere with the expected demand, including daily distribution of macronutrients, physical activity and light exposure, may disrupt the physiologic harmony between predicted and actual behavior. Such a desynchronization may favor the development of a wide range of disease-related processes, including obesity and its comorbidities. Evidence has been provided that the main components of 24-h EE may be affected by disruption of the circadian rhythm. The sleep pattern, meal timing and meal composition could mediate these effects. An increased understanding of the crosstalk between disruption of the circadian rhythm and energy balance may shed light on the pathophysiologic mechanisms underlying weight gain, which may eventually lead to design effective strategies to fight the obesity pandemic.
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DOI：
10.3945/ajcn.115.122044
发表时间：
2016-03
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Chowdhury EA;Richardson JD;Holman GD;Tsintzas K;Thompson D;Betts JA
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影响因子：
4.8
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10.3945/ajcn.114.083402
发表时间：
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期刊：
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影响因子：
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影响因子：
4.9
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影响因子：
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作者：
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