SARS-CoV-2 Mutations and their Viral Variants.
SARS-CoV-2 Mutations and their Viral Variants.
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DOI：
10.1016/j.cytogfr.2021.06.001
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发表时间：
2022-03
影响因子：
13
通讯作者：
Demir-Dora D
中科院分区：
文献类型：
--
作者：
Cosar B;Karagulleoglu ZY;Unal S;Ince AT;Uncuoglu DB;Tuncer G;Kilinc BR;Ozkan YE;Ozkoc HC;Demir IN;Eker A;Karagoz F;Simsek SY;Yasar B;Pala M;Demir A;Atak IN;Mendi AH;Bengi VU;Cengiz Seval G;Gunes Altuntas E;Kilic P;Demir-Dora D
Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occur spontaneously during replication. Thousands of mutations have accumulated and continue to since the emergence of the virus. As novel mutations continue appearing at the scene, naturally, new variants are increasingly observed. Since the first occurrence of the SARS-CoV-2 infection, a wide variety of drug compounds affecting the binding sites of the virus have begun to be studied. As the drug and vaccine trials are continuing, it is of utmost importance to take into consideration the SARS-CoV-2 mutations and their respective frequencies since these data could lead the way to multi-drug combinations. The lack of effective therapeutic and preventive strategies against human coronaviruses (hCoVs) necessitates research that is of interest to the clinical applications. The reason why the mutations in glycoprotein S lead to vaccine escape is related to the location of the mutation and the affinity of the protein. At the same time, it can be said that variations should occur in areas such as the receptor-binding domain (RBD), and vaccines and antiviral drugs should be formulated by targeting more than one viral protein. In this review, a literature survey in the scope of the increasing SARS-CoV-2 mutations and the viral variations is conducted. In the light of current knowledge, the various disguises of the mutant SARS-CoV-2 forms and their apparent differences from the original strain are examined as they could possibly aid in finding the most appropriate therapeutic approaches.
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作者：
Ali F;Kasry A;Amin M
通讯作者：
Amin M
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作者：
Durmaz B;Abdulmajed O;Durmaz R
通讯作者：
Durmaz R
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Corman VM;Muth D;Niemeyer D;Drosten C
通讯作者：
Drosten C
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Gorbalenya AE;Enjuanes L;Ziebuhr J;Snijder EJ
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Snijder EJ
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0.8
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Akter S;Banu TA;Goswami B;Osman E;Uzzaman MS;Habib MA;Jahan I;Mahmud ASM;Sarker MMH;Hossain MS;Shamsuzzaman AKM;Nafisa T;Molla MMA;Yeasmin M;Ghosh AK;Al Din SMS;Ray UC;Sajib SA;Hossain M;Khan MS
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Khan MS