Emergent selectivity for task-relevant stimuli in higher-order auditory cortex.

Emergent selectivity for task-relevant stimuli in higher-order auditory cortex.
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DOI:
10.1016/j.neuron.2014.02.029
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发表时间:
2014-04-16
期刊:
影响因子:
16.2
通讯作者:
Fritz JB
Fritz JB
中科院分区:
医学1区
文献类型:
--
作者:
Atiani S;David SV;Elgueda D;Locastro M;Radtke-Schuller S;Shamma SA;Fritz JB

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初级听觉皮层 (A1) 已证实存在多种与注意力相关的效应。然而,对高级听觉皮层区域在引导对声刺激的注意力方面的功能作用的理解一直难以捉摸。我们记录了接受简单听觉辨别任务训练的雪貂背外外侧回(dPEG)两个音调皮质带区域的神经元。 dPEG 中的神经元表现出与 A1 相似的基本听觉调谐特性,但在行为过程中我们观察到这些区域之间存在显着差异。在带区,神经元放电率和反应动力学的变化大大增强了对目标刺激相对于干扰物的反应,从而在主动聆听期间实现更大的注意力选择。与现有的解剖学证据一致,听觉带皮层的感觉调谐和行为调制模式将 A1 中整个声学场景的频谱时间表征与额叶皮层中观察到的任务相关刺激的更抽象表征联系起来。
A variety of attention-related effects have been demonstrated in primary auditory cortex (A1). However, an understanding of the functional role of higher auditory cortical areas in guiding attention to acoustic stimuli has been elusive. We recorded from neurons in two tonotopic cortical belt areas in the dorsal posterior ectosylvian gyrus (dPEG) of ferrets trained on a simple auditory discrimination task. Neurons in dPEG showed similar basic auditory tuning properties to A1, but during behavior we observed marked differences between these areas. In the belt areas, changes in neuronal firing rate and response dynamics greatly enhanced responses to target stimuli relative to distractors, allowing for greater attentional selection during active listening. Consistent with existing anatomical evidence, the pattern of sensory tuning and behavioral modulation in auditory belt cortex links the spectro-temporal representation of the whole acoustic scene in A1 to a more abstracted representation of task-relevant stimuli observed in frontal cortex.
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发表时间: 2009-03-18
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
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