Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES).
Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES).
复制标题
婴儿期和幼儿期的向上体重百分位数交叉独立预测年轻人的脂肪量：斯德哥尔摩体重发展研究（SWEDES）。
DOI：
10.1093/ajcn/83.2.324
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
S. Rössner
中科院分区：
文献类型：
--
作者：
U. Ekelund;K. Ong;Y. Linné;M. Neovius;S. Brage;D. Dunger;N. Wareham;S. Rössner
背景
出生后早期体重快速增加预示着随后肥胖和相关疾病风险的增加。然而，出生后体重快速增加的确切时间尚不清楚。
目的
目的是研究婴儿期和幼儿期体重快速增加与17岁时身体成分之间的关系。
设计
这项前瞻性队列研究在248例（103例男性）单胎婴儿及其母亲中进行。在出生时、6个月、3岁和6岁时测量身高和体重。婴儿期（0-6个月）和幼儿期（3-6岁）的体重增加率计算为这些时间段内性别和年龄校正的体重SD评分的变化。在17岁时，通过空气置换体积描记法测量身体组成。
结果
婴儿期和幼儿期体重增加均与17岁时较大的体重指数、脂肪量、相对脂肪量、无脂肪量和腰围独立相关（所有P < 0.005;经性别、出生体重、胎龄、当前身高、母亲社会经济状况和母亲脂肪量校正）。婴儿期体重快速增加，而非幼儿期体重快速增加，也预示着17岁时身高较高（P < 0.001）。
结论
婴儿期和幼儿期体重快速增加是成人肥胖症和肥胖症的危险因素。婴儿期体重的快速增加也预示着成年后的身高会更高。我们假设婴儿期和幼儿期体重的快速增加是不同的过程，可能允许在以后的生活中对肥胖风险进行早期干预的单独机会。
BACKGROUND
Rapid early postnatal weight gain predicts increased subsequent obesity and related disease risks. However, the exact timing of adverse rapid postnatal weight gain is unclear.
OBJECTIVE
The objective was to examine the associations between rapid weight gain in infancy and in early childhood in relation to body composition at age 17 y.
DESIGN
This prospective cohort study was conducted in 248 (103 males) singletons and their mothers. Height and weight were measured at birth, 6 mo, and 3 and 6 y. The rates of weight gain during infancy (0-6 mo) and early childhood (3-6 y) were calculated as changes in sex- and age-adjusted weight SD scores during these time periods. At 17 y, body composition was measured by air-displacement plethysmography.
RESULTS
Increasing weight gain during infancy and early childhood were both independently associated with larger body mass index, fat mass, relative fat mass, fat-free mass, and waist circumference at 17 y (P < 0.005 for all; adjusted for sex, birth weight, gestational age, current height, maternal socioeconomic status, and maternal fat mass). Rapid weight gain in infancy, but not in early childhood, also predicted taller height at 17 y (P < 0.001).
CONCLUSIONS
Rapid weight gain in both infancy and early childhood is a risk factor for adult adiposity and obesity. Rapid weight gain in infancy also predicted taller adult height. We hypothesize that rapid weight gains in infancy and early childhood are different processes and may allow separate opportunities for early intervention against obesity risk later in life.
影响因子：
120.7
作者：
Gillman, MW;Rifas-Shiman, SL;Colditz, GA
通讯作者：
Colditz, GA
影响因子：
120.7
作者：
Schulze, MB;Manson, JE;Hu, FB
通讯作者：
Hu, FB
影响因子：
7.1
作者：
DIETZ, WH
通讯作者：
DIETZ, WH