Impact of Genetic Risk Score and Dietary Protein Intake on Vitamin D Status in Young Adults from Brazil.
Impact of Genetic Risk Score and Dietary Protein Intake on Vitamin D Status in Young Adults from Brazil.
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DOI：
10.3390/nu14051015
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发表时间：
2022-02-28
期刊：
影响因子：
5.9
通讯作者：
Vimaleswaran KS
中科院分区：
文献类型：
--
作者：
Alathari BE;Cruvinel NT;da Silva NR;Chandrabose M;Lovegrove JA;Horst MA;Vimaleswaran KS
鉴于维生素D缺乏症（VDD）和代谢疾病的不良后果之间的关系，我们调查了饮食和遗传成分对巴西年轻人维生素D水平和代谢特征的相互作用。对187名健康的年轻人（19-24岁）进行了遗传分析、饮食摄入、人体测量和生化测量。构建了6种与维生素D相关的遗传变异（维生素D-GRS）和10种与代谢疾病相关的遗传变异（代谢-GRS）的遗传风险评分（GRS）。高维生素D-GRS与低25（OH）D浓度显著相关（p = 0.001），高代谢GRS与高空腹胰岛素浓度显著相关（p = 0.045）。发现维生素D-GRS和总蛋白摄入量（g/天）（调整非动物蛋白）对25（OH）D有显著的相互作用（p相互作用= 0.006），其中与携带≤4个风险等位基因的个体相比，摄入高蛋白饮食（≥73 g/d）并携带>4个VDD风险等位基因的个体的25（OH）D显著降低（p = 0.002）。尽管我们的研究并不支持代谢GRS和维生素D状态之间的联系，但我们的研究已经证明了一种新的相互作用，即具有高维生素D-GRS和每天消耗≥73 g蛋白质的参与者的25（OH）D水平显着降低。需要进一步研究来评估动物蛋白质消耗对巴西人VDD的作用。
Given the relationship between vitamin D deficiency (VDD) and adverse outcomes of metabolic diseases, we investigated the interplay of dietary and genetic components on vitamin D levels and metabolic traits in young adults from Brazil. Genetic analysis, dietary intake, and anthropometric and biochemical measurements were performed in 187 healthy young adults (19–24 years). Genetic risk scores (GRS) from six genetic variants associated with vitamin D (vitamin D-GRS) and 10 genetic variants associated with metabolic disease (metabolic-GRS) were constructed. High vitamin D-GRS showed a significant association with low 25(OH)D concentrations (p = 0.001) and high metabolic-GRS showed a significant association with high fasting insulin concentrations (p = 0.045). A significant interaction was found between vitamin D-GRS and total protein intake (g/day) (adjusted for non-animal protein) on 25(OH)D (pinteraction = 0.006), where individuals consuming a high protein diet (≥73 g/d) and carrying >4 risk alleles for VDD had significantly lower 25(OH)D (p = 0.002) compared to individuals carrying ≤4 risk alleles. Even though our study did not support a link between metabolic-GRS and vitamin D status, our study has demonstrated a novel interaction, where participants with high vitamin D-GRS and consuming ≥73 g of protein/day had significantly lower 25(OH)D levels. Further research is necessary to evaluate the role of animal protein consumption on VDD in Brazilians.
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影响因子：
4.8
作者：
Correr CJ;Coura-Vital W;Frade JCQP;Nascimento RCRM;Nascimento LG;Pinheiro EB;Ferreira WM;Reis JS;Melo KFS;Pontarolo R;Lenzi MSA;Almeida JV;Pedrosa HC;João WSJ
通讯作者：
João WSJ
影响因子：
2.1
作者：
Dudbridge F
通讯作者：
Dudbridge F
影响因子：
20.3
作者：
Bouillon R;Marcocci C;Carmeliet G;Bikle D;White JH;Dawson-Hughes B;Lips P;Munns CF;Lazaretti-Castro M;Giustina A;Bilezikian J
通讯作者：
Bilezikian J
影响因子：
--
作者：
Been LF;Ralhan S;Wander GS;Mehra NK;Singh J;Mulvihill JJ;Aston CE;Sanghera DK
通讯作者：
Sanghera DK
影响因子：
2.1
作者：
Souza, Aracele Maria de;Resende, Sarah Stela;Brito, Cristiana Ferreira Alves de
通讯作者：
Brito, Cristiana Ferreira Alves de