Lack of detection of SARS-CoV-2 in British wildlife 2020-21 and first description of a stoat (Mustela erminea) Minacovirus.

Lack of detection of SARS-CoV-2 in British wildlife 2020-21 and first description of a stoat (Mustela erminea) Minacovirus.
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2020-21 年英国野生动物中未检测到 SARS-CoV-2,首次描述了白鼬 (Mustela erminea) Minacovirus。

DOI:
10.1099/jgv.0.001917
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发表时间:
2023-12
影响因子:
3.8
通讯作者:
Tarlinton, Rachael
Tarlinton, Rachael
中科院分区:
医学3区
文献类型:
--
作者:
Apaa, Ternenge;Withers, Amy J.;Mackenzie, Laura;Staley, Ceri;Dessi, Nicola;Blanchard, Adam;Bennett, Malcolm;Bremner-Harrison, Samantha;Chadwick, Elizabeth A.;Hailer, Frank;Harrison, Stephen W. R.;Lambin, Xavier;Loose, Matthew;Mathews, Fiona;Tarlinton, Rachael

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严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)向新宿主的反复溢出突出了冠状病毒跨物种传播和建立新的病毒库在冠状病毒大流行和动物流行传播中的关键作用。特别容易受到SARS-CoV-2溢出影响的物种包括鼬科动物(水貂、雪貂和相关动物)、啮齿类动物(仓鼠和相关动物)、猫科动物(家猫和相关动物)和白尾鹿。这些倾向使我们使用在人类大流行期间收集的样本,用SARS-CoV-2的Sarbecovirus特异性定量PCR和泛冠状病毒PCR检测筛选英国野生动物,以确定是否发生了广泛的溢出。测试了14种野生动物物种(n=402),包括:两只红狐狸(Vulpes vulpes),101只獾(Meles meles),两种野生美洲貂(Neogale vison),41 pine marten(Martes martes),两只黄鼠狼(Mustela nivalis),七只白鼬(Mustela erminea),108只水田鼠(Arvicola amphibius),39只河岸田鼠(Myodes glareolous),10只田鼠(Microtus agrestis),15只木鼠(Apodemus sylvaticus)、一只普通鼩(Sorex aranaeus)、两只侏儒鼩(Sorex minutus)、两只刺猬(Erinaceus europaeus)和75只欧亚水獭(Lutra lutra)。在任何动物中均未检测到SARS-CoV-2病例,但在最近引入奥克尼群岛的白鼬中检测到一种与水貂和雪貂冠状病毒相关的新型Minacovirus。这组病毒由于在雪貂中的致病性而受到关注。这种病毒对白鼬种群健康的影响仍有待确定。
Repeat spillover of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into new hosts has highlighted the critical role of cross-species transmission of coronaviruses and establishment of new reservoirs of virus in pandemic and epizootic spread of coronaviruses. Species particularly susceptible to SARS-CoV-2 spillover include Mustelidae (mink, ferrets and related animals), cricetid rodents (hamsters and related animals), felids (domestic cats and related animals) and white-tailed deer. These predispositions led us to screen British wildlife with sarbecovirus-specific quantitative PCR and pan coronavirus PCR assays for SARS-CoV-2 using samples collected during the human pandemic to establish if widespread spillover was occurring. Fourteen wildlife species (n=402) were tested, including: two red foxes (Vulpes vulpes), 101 badgers (Meles meles), two wild American mink (Neogale vison), 41 pine marten (Martes martes), two weasels (Mustela nivalis), seven stoats (Mustela erminea), 108 water voles (Arvicola amphibius), 39 bank voles (Myodes glareolous), 10 field voles (Microtus agrestis), 15 wood mice (Apodemus sylvaticus), one common shrew (Sorex aranaeus), two pygmy shrews (Sorex minutus), two hedgehogs (Erinaceus europaeus) and 75 Eurasian otters (Lutra lutra). No cases of SARS-CoV-2 were detected in any animals, but a novel minacovirus related to mink and ferret alphacoronaviruses was detected in stoats recently introduced to the Orkney Islands. This group of viruses is of interest due to pathogenicity in ferrets. The impact of this virus on the health of stoat populations remains to be established.
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