Risk factors associated with incident cataracts and cataract surgery in the Age-related Eye Disease Study (AREDS): AREDS report number 32.
Risk factors associated with incident cataracts and cataract surgery in the Age-related Eye Disease Study (AREDS): AREDS report number 32.
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DOI：
10.1016/j.ophtha.2011.03.032
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发表时间：
2011-11
期刊：
影响因子：
13.7
通讯作者：
Age-Related Eye Disease Study Group
中科院分区：
文献类型：
--
作者：
Chang JR;Koo E;Agrón E;Hallak J;Clemons T;Azar D;Sperduto RD;Ferris FL 3rd;Chew EY;Age-Related Eye Disease Study Group
研究与年龄相关的眼病研究（AREDS）中参与者中的核，皮质和后下（PSC）白内障和白内障手术相关的潜在危险因素。
基于诊所的前瞻性队列研究。
患者（n = 4425），年龄在60至80岁之间，参加了抗氧化维生素和矿物质的对照临床试验，AREDS，用于年龄相关的黄斑变性（AMD）和白内障。
使用AREDS系统对核，皮质和PSC的核心进行分级。在最终访问中至少有中等程度，或者使用白内障分析来评估与特定类型的眼睛和白内障手术相关的基线危险因素。
中度白内障定义为核不透性的≥4.0，≥10％的可见透镜中的涉及皮质不透明度，≥5％的透镜中央5 mm圆圈的参与psc不透明度。和年度镜头照片。
基线的4425人在基线时的基于诊所的队列平均为9.8±2.4岁。 PSC和皮质的风险增加；白层的风险增加了PSC的风险；白内障和较高的教育水平，降低了皮质性白内障的风险；
我们的发现在很大程度上与先前研究的结果一致，为与年龄相关的白内障的可能修改风险因素提供了进一步的证据。
To investigate potential risk factors associated with incident nuclear, cortical, and posterior subcapsular (PSC) cataracts and cataract surgery in participants in the Age-Related Eye Disease Study (AREDS). Clinic-based prospective cohort study. Persons (N=4425), aged 60 to 80 years of age enrolled in a controlled clinical trial of antioxidant vitamins and minerals, AREDS, for age-related macular degeneration (AMD) and cataract. Lens photographs were graded centrally for nuclear, cortical, and PSC opacities using the AREDS System for Classifying Cataracts. Type-specific incident cataracts were defined as an increase in cataract grade from none or mild at baseline to a grade of moderate at follow-up, with also a grade of at least moderate at the final visit, or cataract surgery. Cox regression analyses were used to assess baseline risk factors associated with type specific opacities and cataract surgery. Moderate cataract was defined as a grade of ≥4.0 for nuclear opacity, ≥10% involvement within the full visible lens for cortical opacity, and ≥5% involvement of the central 5 mm circle of the lens for PSC opacity. These were graded on baseline and annual lens photographs. A clinic-based cohort of 4425 persons aged 55–80 years at baseline was followed for an average of 9.8 ± 2.4 years. The following associations were found: increasing age with increased risk of all types of cataract and cataract surgery; males with increased risk of PSC and decreased risk of cortical cataracts; non-whites with increased risk of cortical cataract; hyperopia with decreased risk of PSC, nuclear cataract, and cataract surgery; Centrum use with decreased risk of nuclear cataract; diabetes with increased risk of cortical, PSC cataract, and cataract surgery; higher educational level with decreased risk of cortical cataract; and smoking with increased risk of cortical cataract and cataract surgery. Estrogen replacement therapy in female participants increased the risk of cataract surgery. Our findings are largely consistent with the results of previous studies, providing further evidence for possible modifiable risk factors for age-related cataract.
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影响因子：
--
作者：
HANKINSON, SE;SEDDON, JM;WILLETT, WC
通讯作者：
WILLETT, WC
影响因子：
--
作者：
Hennis, A;Wu, SY;Leske, C
通讯作者：
Leske, C
影响因子：
13.7
作者：
Klein, Barbara E. K.;Klein, Ronald;Gangnon, Ronald E.
通讯作者：
Gangnon, Ronald E.
影响因子：
4.2
作者：
Klein, BEK;Klein, R;Lee, KE
通讯作者：
Lee, KE
影响因子：
--
作者：
CHEW, EY;WILLIAMS, GA;FERRIS, FL
通讯作者：
FERRIS, FL