A systematic review and meta-analysis reveal that Campylobacter spp. and antibiotic resistance are widespread in humans in sub-Saharan Africa.
A systematic review and meta-analysis reveal that Campylobacter spp. and antibiotic resistance are widespread in humans in sub-Saharan Africa.
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DOI：
10.1371/journal.pone.0245951
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Bila CG
中科院分区：
文献类型：
--
作者：
Hlashwayo DF;Sigaúque B;Noormahomed EV;Afonso SMS;Mandomando IM;Bila CG
弯曲杆菌属。是引起世界各地人类胃肠炎的人畜共患细菌，其主要症状是腹泻。在某些情况下，可能会出现肠道外表现，如格林-巴利综合征。这种细菌会导致严重的腹泻，主要发生在儿童和免疫功能低下的人身上。本综述旨在解决弯曲杆菌的流行问题。在撒哈拉以南非洲的人类身上。它还旨在了解艾滋病毒对流行率的影响，以及报告关于抗生素耐药性的数据，并提出研究优先事项。我们遵循Prisma指南查找有关弯曲杆菌发生的研究。在撒哈拉以南非洲的所有国家的人类身上。PubMed、Cochrane Library、CINAHL、African Index Medicus、African Journals Online、Google Scholar和Science Direct检索了2000至2020年间发表的研究。我们进行了随机效应荟萃分析，计算了不同抗生素耐药菌株的比例。我们发现，在53个撒哈拉以南非洲国家中的20个国家，有77项研究描述了这种情况在人类中的发生。空肠弯曲杆菌是最常见的菌种。合并患病率为9.9%(CI：8.4%~11.6%)。在不同的亚区内没有发现重大的差异。大多数研究报道了弯曲杆菌属。作为腹泻的原因，主要发生在儿童身上。一些研究报道，这种细菌可能是急性弛缓性麻痹和尿路感染的病原体。弯曲杆菌属。在艾滋病毒感染患者中呈现出较高的混合流行率，尽管在统计上没有显著意义。据报道，包括红霉素和四环素在内的许多抗生素都有很高比例的耐药菌株。弯曲杆菌属。虽然许多国家的信息稀缺或根本不存在，但撒哈拉以南非洲发生了这种情况。研究的优先事项应包括对研究不足的物种进行调查；肠道外表现；艾滋病毒感染的影响和相关的危险因素。应加强控制战略，以遏制这种病原体的传播和耐药性。
Campylobacter spp. are zoonotic bacteria that cause gastroenteritis in humans worldwide, whose main symptom is diarrhea. In certain cases, extra intestinal manifestations may occur, such as Guillain Barré syndrome. The bacteria cause severe diarrhea mostly in children and in immunocompromised individuals. This review aims to address the prevalence of Campylobacter spp. in humans in sub-Saharan Africa. It also aims to understand the impact of HIV in the prevalence, as well as to report data on antibiotic resistance and propose research priorities. We followed PRISMA guidelines to find studies on the occurrence of Campylobacter spp. in humans in all countries from sub-Saharan Africa. Studies published between 2000 and 2020 were searched in PubMed, Cochrane Library, CINAHL, African Index Medicus, African Journals Online, Google Scholar and Science Direct. We have conducted a random-effect meta-analysis and calculated the proportion of resistant isolates to different antibiotics. We found 77 studies that described such occurrence in humans in 20 out of 53 sub-Saharan African countries. Campylobacter jejuni was the most prevalent species. Pooled prevalence was 9.9% (CI: 8.4%–11.6%). No major variations within the different sub-regions were found. Most studies reported Campylobacter spp. as the cause of diarrhea, mainly in children. Some studies reported the bacteria as a possible etiologic agent of acute flaccid paralysis and urinary tract infection. Campylobacter spp. presented a higher pooled prevalence in HIV infected patients, although not statistically significant. High proportions of resistant strains were reported for many antibiotics, including erythromycin and tetracycline. Campylobacter spp. occur in sub-Saharan Africa, although information is scarce or inexistent for many countries. Research priorities should include investigation of the understudied species; extra intestinal manifestations; the impact of HIV infection and associated risk factors. Control strategies should be reinforced to contain the spread of this pathogen and drug resistance.
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影响因子：
3.3
作者：
Deogratias, Anna-Pendo;Mushi, Martha;Mshana, Stephen
通讯作者：
Mshana, Stephen
DOI：
10.1016/s1201-9712(01)90069-4
发表时间：
2001-01-01
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Gassama, A;Sow, P S;Aidara-Kane, A
通讯作者：
Aidara-Kane, A
DOI：
10.1097/mpg.0000000000001323
发表时间：
2017-01-01
影响因子：
2.9
作者：
Gosselin, Kerri B.;Aboud, Said;Duggan, Christopher
通讯作者：
Duggan, Christopher
影响因子：
3.7
作者：
Chuma IS;Nonga HE;Mdegela RH;Kazwala RR
通讯作者：
Kazwala RR
影响因子：
2.8
作者：
Ewnetu, Desalegne;Mihret, Adane
通讯作者：
Mihret, Adane