Liposomal hamycin: reduced toxicity and improved antifungal efficacy in vitro and in vivo.
Liposomal hamycin: reduced toxicity and improved antifungal efficacy in vitro and in vivo.
复制标题
脂质体哈霉素：降低毒性并提高体外和体内抗真菌功效。
DOI：
10.1093/infdis/164.5.1003
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Lopez-Berestein,G
中科院分区：
文献类型：
--
作者：
Mehta,RT;McQueen,TJ;Keyhani,A;Lopez-Berestein,G
Hamycin has been used to treat a variety of yeast and other fungal infections by oral, topical, and intraperitoneal routes. However, its parenteral use has been reported to be associated with high toxicity. Multilamellar liposomes composed of dimyristoyl phosphatidyl choline, dimyristoyl phosphatidyl glycerol, and various amounts of cholesterol were used as drug carriers for hamycin. The antifungal activity of hamycin was maintained after liposome encapsulation (MIC range, 0.6–1.2 µg/ml), and toxicity was reduced in vitro and in vivo as the concentration of cholesterol was increased to an appropriate ratio. Mice were treated with various doses of free or liposomal hamycin 2 days after infection. Although free drug did not significantly improve survival, liposomal hamycin at an equivalent dose (0.6 rug/kg) increased the survival from 18 to 38 days. Higher doses (1.2 and 1.8 mg/kg) showed further improvement in survival and reduction in numbers of colony-forming units in the kidneys. Liposome encapsulation resulted in improved therapeutic index of hamycin.
登录
查看更多内容
两性霉素 B 和脂质体包裹的两性霉素 B 的体外抗真菌活性
影响因子：
4.9
作者：
R. Hopfer;K. Mills;R. Mehta;G. Lopez;V. Fainstein;R. Juliano
通讯作者：
R. Juliano
用脂质体封装的两性霉素 B 治疗和预防小鼠白色念珠菌播散性感染。
DOI：
10.1093/infdis/147.5.939
发表时间：
1983
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
G. Lopez;R. Mehta;R. Hopfer;K. Mills;L. Kasi;K. Mehta;V. Fainstein;M. Luna;Evan M. Hersh;Rudolph L. Juliano
通讯作者：
Rudolph L. Juliano
DOI：
10.7164/antibiotics.30.158
发表时间：
1977
期刊：
The Journal of antibiotics
影响因子：
--
作者：
R. C. Pandey;K. Rinehart
通讯作者：
K. Rinehart
Hamycin：在小鼠中分离毒性和抗真菌活性。
影响因子：
6.1
作者：
A. C. Parekh;C. Dave
通讯作者：
C. Dave
哈霉素：人类全身性真菌病的化疗研究。
DOI：
10.1164/arrd.1967.95.3.506
发表时间：
1967
期刊：
The American review of respiratory disease
影响因子：
--
作者：
J. Utz;P. Witorsch;T. W. Williams;C. W. Emmons;H. J. Shadomy;W. Piggott
通讯作者：
W. Piggott