A multimodal neuroimaging study investigating resting-state connectivity, glutamate and GABA at 7 T in first-episode psychosis.
A multimodal neuroimaging study investigating resting-state connectivity, glutamate and GABA at 7 T in first-episode psychosis.
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DOI：
10.1503/jpn.210107
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Lahti AC
中科院分区：
文献类型：
--
作者：
Overbeek G;Gawne TJ;Reid MA;Kraguljac NV;Lahti AC
脑内主要兴奋性和抑制性神经代谢物谷氨酸和γ-氨基丁酸（γ-氨基丁酸，GABA）分别与功能性MRI信号有关。静息状态功能性MRI信号的中断在精神病谱系障碍中已有报道，但很少有研究调查这些代谢物在这种情况下的作用。我们纳入了19名首发精神病患者和21名健康对照，进行了磁共振波谱（MRS）和静息状态功能连接的联合研究。所有成像均在Siemens Magnetom 7t MRI扫描仪上进行。MRS体素和功能连通性分析的种子都位于前扣带皮层背侧（ACC）。我们使用多元回归来检验ACC脑连通性、诊断和神经代谢物之间的相互作用。ACC脑连通性在首发精神病中发生改变。首发精神病患者与健康对照在楔前叶、脾后皮质、边缘上回和角回中ACC谷氨酸与ACC功能连通性的关系存在差异。ACC GABA与ACC功能连通性的关系在尾状核、壳核和边缘上回中也存在差异。我们的样本量很小。同样，尽管他们没有长期服药，但所有参与者在研究期间都服用了药物。我们证明了健康参与者中主要兴奋性和抑制性脑代谢物与静息状态功能连接之间的联系，以及首发精神病患者中这种关系的改变。结合不同成像方式的数据可能有助于我们对主要神经代谢物与脑网络动力学之间关系的机制理解，并阐明首发精神病的病理生理学。
The major excitatory and inhibitory neurometabolites in the brain, glutamate and γ-aminobutyric acid (GABA), respectively, are related to the functional MRI signal. Disruption of resting-state functional MRI signals has been reported in psychosis spectrum disorders, but few studies have investigated the role of these metabolites in this context. We included 19 patients with first-episode psychosis and 21 healthy controls in this combined magnetic resonance spectroscopy (MRS) and resting-state functional connectivity study. All imaging was performed on a Siemens Magnetom 7 T MRI scanner. Both the MRS voxel and the seed for functional connectivity analysis were located in the dorsal anterior cingulate cortex (ACC). We used multiple regressions to test for an interaction between ACC brain connectivity, diagnosis and neurometabolites. ACC brain connectivity was altered in first-episode psychosis. The relationship between ACC glutamate and ACC functional connectivity differed between patients with first-episode psychosis and healthy controls in the precuneus, retrosplenial cortex, supramarginal gyrus and angular gyrus. As well, the relationship between ACC GABA and ACC functional connectivity differed between groups in the caudate, putamen and supramarginal gyrus. We used a small sample size. As well, although they were not chronically medicated, all participants were medicated during the study. We demonstrated a link between the major excitatory and inhibitory brain metabolites and resting-state functional connectivity in healthy participants, as well as an alteration in this relationship in patients with first-episode psychosis. Combining data from different imaging modalities may help our mechanistic understanding of the relationship between major neurometabolites and brain network dynamics, and shed light on the pathophysiology of first-episode psychosis.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1016/j.nicl.2015.11.015
发表时间：
2016
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Kraguljac NV;White DM;Hadley JA;Visscher K;Knight D;ver Hoef L;Falola B;Lahti AC
通讯作者：
Lahti AC
影响因子：
4.5
作者：
Ebisch, Sjoerd J. H.;Gallese, Vittorio;Northoff, Georg
通讯作者：
Northoff, Georg
影响因子：
6.6
作者：
Kraguljac, Nina Vanessa;White, David Matthew;Lahti, Adrienne Carol
通讯作者：
Lahti, Adrienne Carol
影响因子：
4.2
作者：
Falkenberg, Liv E.;Westerhausen, Rene;Hugdahl, Kenneth
通讯作者：
Hugdahl, Kenneth