Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.
Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.
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DOI：
10.4049/jimmunol.0904190
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发表时间：
2011-03-01
期刊：
影响因子：
--
通讯作者：
Wright JR
中科院分区：
文献类型：
--
作者：
Pastva AM;Mukherjee S;Giamberardino C;Hsia B;Lo B;Sempowski GD;Wright JR
Although many studies show that pulmonary Surfactant Protein A (SP-A) functions in innate immunity, fewer studies have addressed its role in adaptive immunity and allergic hypersensitivity. We hypothesized that SP-A modulates the phenotype and prevalence of dendritic cells (DCs) and CD4+ T cells to inhibit Th2-associated inflammatory indices associated with allergen-induced inflammation. In an ovalbumin (OVA) model of allergic hypersensitivity, SP-A deficient (SP-A−/−) mice had greater eosinophilia, Th2-associated cytokine levels, and IgE levels compared to wild-type (WT) counterparts. Although both OVA-exposed groups had similar proportions of CD86+ DCs and Foxp3+ T regulatory cells, the SP-A−/− mice had elevated proportions of CD4+ activated (TA) and effector memory (TEM) T cells in their lungs compared to WT mice. Ex vivo recall stimulation of CD4+ T cell pools demonstrate that the cells from the SP-A−/− OVA mice had the greatest proliferative and IL-4 producing capacity, and this capability was attenuated with exogenous SP-A treatment. Additionally, tracking proliferation in vivo demonstrated that TA and TEM cells expand to the greatest extent in the lungs of SP-A−/− OVA mice. Taken together, our data suggest that SP-A influences the prevalence, types, and functions of CD4+ T cells in the lungs during allergic inflammation and that surfactant protein deficiency modifies the severity of inflammation in allergic hypersensitivity conditions like asthma.
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影响因子：
1.7
作者：
ANSFIELD, MJ;KALTREIDER, HB;SHALABY, MR
通讯作者：
SHALABY, MR
DOI：
10.1164/ajrccm/146.2.500
发表时间：
1992-08-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
BENTLEY, AM;MENZ, G;KAY, AB
通讯作者：
KAY, AB
DOI：
10.1152/ajplung.1998.275.4.l679
发表时间：
1998-10-01
影响因子：
4.9
作者：
Borron, P;McCormack, FX;Fraher, LJ
通讯作者：
Fraher, LJ
影响因子：
4.4
作者：
Campbell, JJ;Brightling, CE;Wardlaw, AJ
通讯作者：
Wardlaw, AJ
小鼠B7-2 costimulator的组织分布：在原位和体外成熟期间在树突状细胞上表达丰富的表达。
影响因子：
15.3
作者：
Inaba, K.;Witmer-Pack, M.;Inaba, M.;Hathcock, K. S.;Sakuta, H.;Azuma, M.;Yagita, H.;Okumura, K.;Linsley, P. S.;Ikehara, S.;Muramatsu, S.;Hodes, R. J.;Steinman, R. M.
通讯作者：
Steinman, R. M.