Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease.
Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease.
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DOI：
10.1186/s13195-018-0413-8
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发表时间：
2018-08-18
期刊：
影响因子：
--
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Vipin A;Loke YM;Liu S;Hilal S;Shim HY;Xu X;Tan BY;Venketasubramanian N;Chen CL;Zhou J
遗忘性轻度认知障碍 (aMCI) 和阿尔茨海默病 (AD) 患者的默认模式网络 (DMN) 中显示功能和结构连接变化，而脑血管疾病 (CeVD) 患者的执行控制网络 (ECN) 中显示功能和结构连接变化。这种破坏分别与记忆和执行功能损伤有关。 AD 和 CeVD 病理学并发与较高的认知能力下降率和不同的神经退行性模式相关。总之，这些发现可能反映了患有和不患有 CeVD 的 AD 中不同的潜在病理学。然而，很少有研究使用假设驱动的基于多种子的方法来研究 CeVD 对 aMCI 和 AD 中 DMN 和 ECN 的网络功能连接（无任务功能磁共振成像（fMRI））和结构连接（扩散 MRI）的影响。我们检查了 39 名 aMCI、50 名 aMCI+CeVD、47 名 AD、47 名 AD+CeVD 和 65 名健康对照 (HC) 的功能和结构连接网络变化及其与执行/注意力和记忆领域认知障碍的关系。我们展示了 CeVD 和非 CeVD 受试者中不同的 DMN 和 ECN 功能连接变化。与对照组相比，AD和AD+CeVD中DMN内海马功能连接均减少，而AD+CeVD和aMCI+CeVD中DMN内顶叶和内侧前额叶-顶叶功能连接较高，但AD较低。 CeVD 受试者中 ECN 内额叶功能连接增加，额顶叶功能连接减少，但非 CeVD 受试者则不然。这种功能连接改变以分离的方式与认知障碍相关：DMN内功能连接变化主要与非CeVD组的较差认知相关，而ECN内功能连接变化主要与CeVD组较差的认知相关。此外，CeVD 和非 CeVD 组根据疾病严重程度，在网络间 DMN-ECN 功能连接方面表现出重叠和独特的变化。与功能连接相反，在 aMCI 和 AD 患者中，与非 CeVD 组相比，CeVD 组的网络结构连接损伤更大。网络结构连接损坏与较差的认知能力相关。我们通过潜在的特定领域认知障碍的不同且有害的基于网络的退化，证明了患有或不患有 CeVD 的 aMCI 和 AD 患者之间不同的功能和结构网络变化。本文的在线版本 (10.1186/s13195-018-0413-8) 包含补充材料，可供授权用户使用。
Patients with amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) show functional and structural connectivity alterations in the default mode network (DMN) while cerebrovascular disease (CeVD) shows functional and structural connectivity changes in the executive control network (ECN). Such disruptions are associated with memory and executive function impairment, respectively. Concurrent AD and CeVD pathology is associated with a higher rate of cognitive decline and differential neurodegenerative patterns. Together, such findings are likely reflective of different underlying pathology in AD with and without CeVD. However, few studies have examined the effect of CeVD on network functional connectivity (task-free functional magnetic resonance imaging (fMRI)) and structural connectivity (diffusion MRI) of the DMN and ECN in aMCI and AD using a hypothesis-driven multiple seed-based approach. We examined functional and structural connectivity network changes in 39 aMCI, 50 aMCI+CeVD, 47 AD, 47 AD+CeVD, and 65 healthy controls (HCs) and their associations with cognitive impairment in the executive/attention and memory domains. We demonstrate divergent DMN and ECN functional connectivity changes in CeVD and non-CeVD subjects. Compared with controls, intra-DMN hippocampal functional connectivity reductions were observed in both AD and AD+CeVD, while intra-DMN parietal and medial prefrontal-parietal functional connectivity was higher in AD+CeVD and aMCI+CeVD, but lower in AD. Intra-ECN frontal functional connectivity increases and fronto-parietal functional connectivity decreases occurred in CeVD but not non-CeVD subjects. Such functional connectivity alterations were related with cognitive impairment in a dissociative manner: intra-DMN functional connectivity changes were associated with worse cognition primarily in non-CeVD groups, while intra-ECN functional connectivity changes were associated with worse cognition primarily in CeVD groups. Additionally, CeVD and non-CeVD groups showed overlapping and distinct alterations in inter-network DMN-ECN functional connectivity depending on disease severity. In contrast to functional connectivity, CeVD groups had greater network structural connectivity damage compared with non-CeVD groups in both aMCI and AD patients. Network structural connectivity damage was associated with worse cognition. We demonstrate differential functional and structural network changes between aMCI and AD patients with and without CeVD through diverging and deleterious network-based degeneration underlying domain-specific cognitive impairment. The online version of this article (10.1186/s13195-018-0413-8) contains supplementary material, which is available to authorized users.
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DOI：
10.1093/brain/awx224
发表时间：
2017-11-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Chong JSX;Liu S;Loke YM;Hilal S;Ikram MK;Xu X;Tan BY;Venketasubramanian N;Chen CL;Zhou J
通讯作者：
Zhou J
影响因子：
4.8
作者：
Hirsiger, Sarah;Koppelmans, Vincent;Jaencke, Lutz
通讯作者：
Jaencke, Lutz
DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
作者：
Chan, Micaela Y.;Park, Denise C.;Wig, Gagan S.
通讯作者：
Wig, Gagan S.
影响因子：
8.3
作者：
Kapeller, P;Barber, R;Fazekas, F
通讯作者：
Fazekas, F
影响因子：
2.1
作者：
Hilal, Saima;Saini, Monica;Venketasubramanian, Narayanaswamy
通讯作者：
Venketasubramanian, Narayanaswamy