Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis.
Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis.
复制标题
非靶向、C-或 N-pH（低）插入肽修饰的超顺磁性氧化铁纳米团簇用于肝肿瘤选择性 MRI 的评估及其在肝硬化中的潜在毒性
作者：
用pH（低）插入肽（pHLIP）修饰的超顺磁性氧化铁纳米团簇（SPION）由于在肿瘤标志物未知时对肿瘤酸性微环境具有独特的响应性，因此有利于肝脏肿瘤的早期磁共振成像（MRI）诊断。然而，许多关键方面需要充分评估，包括选择性 MRI 对肝脏肿瘤的有效性、分娩类型以及肝硬化的潜在安全性。在这项研究中，我们报告了非靶向、C-或N-pHLIP修饰的SPION作为肝脏肿瘤选择性MRI造影剂的评估及其在肝硬化中的潜在毒性特征。结果发现，N-pHLIP 修饰的 SPION 不会导致 T2 权重 MRI 中肝肿瘤的丢失，但提供了肿瘤结构的额外动态细节，这将增强对小于 8 毫米的小尺寸肝肿瘤的诊断。此外，N-pHLIP 修饰的 SPION 的安全性得到了增强，对肝硬化的影响几乎完全可恢复。相比之下，聚-d-赖氨酸组装的 SPION 和 C 末端连接的 pHLIP SPION 具有非肿瘤特异性 MRI 对比度增强，并且由于注射后铁过载而存在肝硬化的潜在安全风险。所有这些结果都表明 N 末端连接的 pHLIP SPION 作为 MRI 造影剂用于诊断肝脏肿瘤的巨大潜力。
Superparamagnetic iron oxide nanoclusters (SPIONs) modified with pH (low) insertion peptide (pHLIP) could be advantageous for magnetic resonance imaging (MRI) diagnosis of liver tumors at the early stage due to their unique responsiveness to the tumor acidic microenvironment when tumor markers are unknown. However, many critical aspects including the effectiveness of selective MRI in liver tumors, types of delivery and the potential safety profile in cirrhosis need to be fully evaluated. In this study, we report the evaluation of non-targeting, C- or N-pHLIP modified SPIONs as the contrast agent for selective MRI of liver tumors and their potential toxicity profile in cirrhosis. It was found that N-pHLIP modified SPIONs did not result in the loss of liver tumor in the T2-weight MRI but provided additional dynamic details of tumor structures that would enhance the diagnosis of liver tumors at a small size below 8 mm. In addition, an enhanced safety profile was found for N-pHLIP modified SPIONs with almost fully recoverable impact in cirrhosis. In contrast, the poly-d-lysine assembled SPIONs and C-terminus linked pHLIP SPIONs had non-tumor specific MRI contrast enhancement and potential safety risks in cirrhosis due to the iron overload post injection. All these results implied the promising potential of N-terminus linked pHLIP SPIONs as an MRI contrast agent for the diagnosis of liver tumors.
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影响因子：
13.5
作者：
Llovet, Josep M.;Bruix, Jordi
通讯作者：
Bruix, Jordi
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影响因子：
3.9
作者：
Hu, Jinming;Qian, Yinfeng;Liu, Shiyong
通讯作者：
Liu, Shiyong
影响因子：
12.4
作者：
Mirshafiee, Vahid;Jiang, Wen;Xia, Tian
通讯作者：
Xia, Tian
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影响因子：
5.8
作者：
Ma, Hui Li;Xu, Yu Feng;Nagai, Tsuneji
通讯作者：
Nagai, Tsuneji
DOI：
10.1016/j.mattod.2015.08.022
发表时间：
2016-04
期刊：
Materials today (Kidlington, England)
影响因子：
--
作者：
Revia RA;Zhang M
通讯作者：
Zhang M