Shape, loading, and motion in the bioengineering design, fabrication, and testing of personalized synovial joints.
Shape, loading, and motion in the bioengineering design, fabrication, and testing of personalized synovial joints.
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DOI：
10.1016/j.jbiomech.2009.09.021
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发表时间：
2010-01-05
影响因子：
2.4
通讯作者：
Sah RL
中科院分区：
文献类型：
--
作者：
Williams GM;Chan EF;Temple-Wong MM;Bae WC;Masuda K;Bugbee WD;Sah RL
随着组织工程治疗小关节病变的不断发展和完善，部分或全部滑膜关节工程化的挑战日益受到关注。关节尺度结构可应用于治疗大面积关节损伤或严重退变关节的生物关节置换术。本文综述了滑膜关节的形态、载荷和运动在滑膜关节力学生物学中的作用以及它们在工程关节的设计、制造和测试中的作用。退行性变的发生率、损伤程度和当前治疗方法的有效性是选择联合生物工程靶点的关键因素。天然关节的形式和功能可以指导工程关节规模结构的设计，包括大小、形状和成熟度。关节规模工程的制造挑战包括控制化学-机械-生物微环境以促进具有完整界面或润滑表面的多个组织的发育和生长，以及关节规模生物反应器通过负载和运动来滋养和刺激组织。最后，承载和摩擦学性能的评估可以从组织到关节规模，并可以侧重于目前或适应后的生物结构。
With continued development and improvement of tissue engineering therapies for small articular lesions, increased attention is being focused on the challenge of engineering partial or whole synovial joints. Joint-scale constructs could have applications in the treatment of large areas of articular damage or in biological arthroplasty of severely degenerate joints. This review considers the roles of shape, loading and motion in synovial joint mechanobiology and their incorporation into the design, fabrication, and testing of engineered partial or whole joints. Incidence of degeneration, degree of impairment, and efficacy of current treatments are critical factors in choosing a target for joint bioengineering. The form and function of native joints may guide the design of engineered joint-scale constructs with respect to size, shape, and maturity. Fabrication challenges for joint-scale engineering include controlling chemo-mechano-biological microenvironments to promote the development and growth of multiple tissues with integrated interfaces or lubricated surfaces into anatomical shapes, and joint-scale bioreactors which nurture and stimulate the tissue with loading and motion. Finally, evaluation of load-bearing and tribological properties can range from tissue to joint scale and can focus on biological structure at present or after adaptation.
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影响因子：
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