Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder
Common and Specific Functional Activity Features in Schizophrenia, Major Depressive Disorder, and Bipolar Disorder
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精神分裂症、重度抑郁症和双相情感障碍的常见和特定功能活动特征
DOI：
10.3389/fpsyt.2019.00052
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发表时间：
2019-02
影响因子：
4.7
通讯作者：
Lv Luxian
中科院分区：
文献类型：
--
作者：
Yang Yongfeng;Liu Shu;Jiang Xiaoyan;Yu Hongyan;Ding Shuang;Lu Yanli;Li Wenqiang;Zhang Hongxing;Liu Bing;Cui Yue;Fan Lingzhong;Jiang Tianzi;Lv Luxian
目的：精神分裂症（SZ）、重性抑郁障碍（MDD）和双相情感障碍（BD）是具有不同诊断标准的严重精神障碍。它们具有共同的临床和生物学特征。然而，目前对这三种精神障碍共同的和特异性的脑影像学改变的研究仍然很少。因此，本研究的目的是确定SZ、MDD和BD的共同和特异性功能活动和连接变化。研究方法：共有271名患者接受了功能性磁共振成像：SZ（n = 64），MDD（n = 73），BD（n = 41）和健康对照（n = 93）。采用阳性和阴性症状量表对SZ患者的症状进行评定。采用Beck抑郁量表（BDI）、Beck焦虑量表（BAI）评定抑郁症患者的症状。采用BDI、BAI和Young躁狂量表对MDD和BD患者进行评定。此外，我们使用两个样本t检验比较了三种精神障碍和健康对照之间的fALFF和功能连接。结果如下：SZ、MDD和BD患者右侧额上级回、扣带回中部、左侧额中回的功能活动显著降低，额叶皮层的功能连接（FC）降低。SZ患者的fALFF改变主要发生在腹外侧前额叶皮质、纹状体和丘脑，MDD患者的fALFF改变主要发生在左侧运动皮质和顶叶，BD患者的fALFF改变主要发生在背外侧前额叶皮质、眶额皮质和后扣带回皮质。结论：我们在SZ、MDD和BD中发现的常见异常提供了证据，表明显著性网络异常可能在这三种精神障碍的发病机制中起关键作用。同时，我们的研究结果还表明，SZ，MDD和BD的特异性改变为这三种精神疾病的鉴别诊断提供了神经影像学证据。
Objectives: Schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD) are serious mental disorders with distinct diagnostic criteria. They share common clinical and biological features. However, there are still only few studies on the common and specific brain imaging changes associated with the three mental disorders. Therefore, the aim of this study was to identify the common and specific functional activity and connectivity changes in SZ, MDD, and BD. Methods: A total of 271 individuals underwent functional magnetic resonance imaging: SZ (n = 64), MDD (n = 73), BD (n = 41), and healthy controls (n = 93). The symptoms of SZ patients were evaluated by the Positive and Negative Syndrome Scale. The Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were used to evaluate the symptoms of MDD patients. The BDI, BAI, and Young Mania Rating Scale were used to evaluate the symptoms of MDD and BD patients. In addition, we compared the fALFF and functional connectivity between the three mental disorders and healthy controls using two sample t-tests. Results: Significantly decreased functional activity was found in the right superior frontal gyrus, middle cingulate gyrus, left middle frontal gyrus, and decreased functional connectivity (FC) of the insula was found in SZ, MDD, and BD. Specific fALFF changes, mainly in the ventral lateral pre-frontal cortex, striatum, and thalamus were found for SZ, in the left motor cortex and parietal lobe for MDD, and the dorsal lateral pre-frontal cortex, orbitofrontal cortex, and posterior cingulate cortex in BD. Conclusion: Our findings of common abnormalities in SZ, MDD, and BD provide evidence that salience network abnormality may play a critical role in the pathogenesis of these three mental disorders. Meanwhile, our findings also indicate that specific alterations in SZ, MDD, and BD provide neuroimaging evidence for the differential diagnosis of the three mental disorders.
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