Common health conditions in childhood and adolescence, school absence, and educational attainment: Mendelian randomization study.
Common health conditions in childhood and adolescence, school absence, and educational attainment: Mendelian randomization study.
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DOI：
10.1038/s41539-020-00080-6
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发表时间：
2021-01-04
影响因子：
4.2
通讯作者：
Howe LD
中科院分区：
文献类型：
--
作者：
Hughes A;Wade KH;Dickson M;Rice F;Davies A;Davies NM;Howe LD
良好的健康状况与儿童的教育成果呈正相关，但关系可能不是因果关系。证明因果影响将有力地支持儿童和青少年健康对教育政策的重要性。我们应用遗传因果推理方法来评估10岁（小学/小学）和13岁（中学/高中）的常见健康状况与16岁时的教育程度和14-16岁时的缺课之间的因果关系。参与者是6113名来自雅芳家长和儿童纵向研究（ALSPAC）的儿童。暴露的症状是注意力缺陷多动障碍（ADHD），自闭症谱系障碍（ASD），抑郁症，哮喘，偏头痛和BMI。这些条件和BMI的遗传易感性是由多基因评分指数。在非遗传的多变量调整模型中，除了哮喘和偏头痛，所有的健康状况都与成绩差和缺课有关。缺课主要介导BMI（13岁时BMI为39.9%）和偏头痛（10岁时为72.0%）对学业成绩的影响，对情绪和神经发育状况的影响更小。在遗传模型中，标准化BMI每增加一个单位，预测标准差为0.19。降低（95% CI：16岁时的成绩平均下降0.11，0.28），相当于所有科目的成绩平均下降约1/3，缺课率增加8.7%（95%CI：1.8%，16.1%）。13岁时的关联相似。ADHD的遗传倾向预测了较低的成就，但不是更多的缺席。多种方法的三角测量支持BMI和ADHD对教育结果的因果性负面影响，但不是ASD，抑郁症，哮喘或偏头痛。儿童和青少年时期较高的BMI可能会损害教育成果。
Good health is positively related to children’s educational outcomes, but relationships may not be causal. Demonstrating a causal influence would strongly support childhood and adolescent health as important for education policy. We applied genetic causal inference methods to assess the causal relationship of common health conditions at age 10 (primary/elementary school) and 13 (mid-secondary/mid-high school) with educational attainment at 16 and school absence at 14–16. Participants were 6113 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Exposures were symptoms of attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), depression, asthma, migraines and BMI. Genetic liability for these conditions and BMI was indexed by polygenic scores. In non-genetic, multivariate-adjusted models, all health conditions except asthma and migraines were associated with poorer attainment and greater school absence. School absence substantially mediated effects of BMI (39.9% for BMI at 13) and migraines (72.0% at 10), on attainment with more modest mediation for emotional and neurodevelopmental conditions. In genetic models, a unit increase in standardized BMI at 10 predicted a 0.19 S.D. decrease (95% CI: 0.11, 0.28) in attainment at 16, equivalent to around a 1/3 grade lower in all subjects, and 8.7% more school absence (95% CI:1.8%,16.1%). Associations were similar at 13. Genetic liability for ADHD predicted lower attainment but not more absence. Triangulation across multiple approaches supports a causal, negative influence on educational outcomes of BMI and ADHD, but not of ASD, depression, asthma or migraine. Higher BMI in childhood and adolescence may causally impair educational outcomes.
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影响因子：
4.9
作者：
Booth, J. N.;Tomporowski, P. D.;Boyle, J. M. E.;Ness, A. R.;Joinson, C.;Leary, S. D.;Reilly, J. J.
通讯作者：
Reilly, J. J.
DOI：
10.1136/bmj.k601
发表时间：
2018-07-12
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Davies NM;Holmes MV;Davey Smith G
通讯作者：
Davey Smith G
影响因子：
4.4
作者：
Davies J;Sullivan S;Zammit S
通讯作者：
Zammit S
影响因子：
7.2
作者：
Boyd A;Tilling K;Cornish R;Davies A;Humphries K;Macleod J
通讯作者：
Macleod J
DOI：
10.1097/01.chi.0000046865.56865.79
发表时间：
2003-07-01
影响因子：
13.3
作者：
Egger, HL;Costello, EJ;Angold, A
通讯作者：
Angold, A