Effects of Condensation on Peri-implant Bone Density and Remodeling

Effects of Condensation on Peri-implant Bone Density and Remodeling
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压缩对种植体周围骨密度和重塑的影响

DOI:
10.1177/0022034516683932
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发表时间:
2017-01
影响因子:
7.6
通讯作者:
J.A. Helms
J.A. Helms
中科院分区:
医学1区
文献类型:
--
作者:
Wang Liao;Y. Wu;K.C. Perez;S. Hyman;J.B. Brunski;U. Tulu;C. Bao;B. Salmon;J.A. Helms

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骨凝结被认为可以致密界面骨,从而提高种植体的初期稳定性,但也缺乏数据支持。我们开发了一个小鼠口腔种植模型来验证这些假说。在愈合的上颌骨拔出部位,1)通过钻孔或2)通过钻孔,然后与锥形截骨器逐步压缩,形成截骨术。冷凝增加了界面骨密度,这是通过骨体积/总体积和骨小梁间距的显著变化来衡量的,但它同时也破坏了骨。植入后第1天,致密的骨界面显示微骨折和破骨细胞活性。有限元建模、力学测试和免疫组织化学分析表明,在整个骨整合过程中的多个时间点,冷凝导致了非常高的界面应变,边缘骨吸收,并且没有改善种植体的稳定性。总而言之,这些多尺度分析表明,冷凝对植入物的稳定性没有积极的贡献
Bone condensation is thought to densify interfacial bone and thus improve implant primary stability, but scant data substantiate either.claim. We developed a murine oral implant model to test these hypotheses. Osteotomies were created in healed maxillary extraction.sites 1) by drilling or 2) by drilling followed by stepwise condensation with tapered osteotomes. Condensation increased interfacial bone.density, as measured by a significant change in bone volume/total volume and trabecular spacing, but it simultaneously damaged the.bone. On postimplant day 1, the condensed bone interface exhibited microfractures and osteoclast activity. Finite element modeling,.mechanical testing, and immunohistochemical analyses at multiple time points throughout the osseointegration period demonstrated.that condensation caused very high interfacial strains, marginal bone resorption, and no improvement in implant stability. Collectively,.these multiscale analyses demonstrate that condensation does not positively contribute to implant stability
DOI: 10.1016/j.bone.2013.07.021
发表时间: 2014-01
期刊: Bone
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