Phase advancing the human circadian clock with blue-enriched polychromatic light.
Phase advancing the human circadian clock with blue-enriched polychromatic light.
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DOI：
10.1016/j.sleep.2008.05.005
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发表时间：
2009-03
期刊：
影响因子：
4.8
通讯作者：
Eastman, Charmane I.
中科院分区：
文献类型：
--
作者：
Smith, Mark R.;Revell, Victoria L.;Eastman, Charmane I.
先前的研究表明，人类昼夜节律系统对短波长（蓝色）光最为敏感。是否可以利用这种灵敏度来增加相移的大小使用灯箱和协议设计的实际设置是未知的。我们评估了富含可见光谱短波长部分的明亮多色灯是否能比标准亮白灯产生更大的相位超前。22名健康的年轻人在4天的治疗中，每天醒来时接受亮白色或亮蓝色的2小时相位推进光脉冲。在第一个治疗日，光脉冲在昏暗褪黑激素开始（DLMO）后8小时开始，平均在基线清醒时间前2小时左右。随后的每一天，光照治疗都比前一天提前一小时开始，睡眠时间也提前了。富蓝组（92±78分钟，n = 12）与白组（76±45分钟，n = 10） DLMO期程无显著差异。在常用的治疗光水平下，明亮的富含蓝色的多色光并不比标准的强光疗法更有效。
Previous studies have shown that the human circadian system is maximally sensitive to short wavelength (blue) light. Whether this sensitivity can be utilized to increase the size of phase shifts using light boxes and protocols designed for practical settings is not known. We assessed whether bright polychromatic lamps enriched in the short wavelength portion of the visible light spectrum could produce larger phase advances than standard bright white lamps. Twenty-two healthy young adults received either a bright white or bright blue-enriched 2-hour phase advancing light pulse upon awakening on each of four treatment days. On the first treatment day the light pulse began 8 hours after the dim light melatonin onset (DLMO), on average about 2 hours before baseline wake time. On each subsequent day, light treatment began one hour earlier than the previous day, and the sleep schedule was also advanced. Phase advances of the DLMO for the blue-enriched (92 ± 78 minutes, n = 12) and white groups (76 ± 45 minutes, n = 10) were not significantly different. Bright blue-enriched polychromatic light is no more effective than standard bright light therapy for phase advancing circadian rhythms at commonly used therapeutic light levels.
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