Are Food Animals Responsible for Transfer of Antimicrobial-Resistant Escherichia coli or Their Resistance Determinants to Human Populations? A Systematic Review.
Are Food Animals Responsible for Transfer of Antimicrobial-Resistant Escherichia coli or Their Resistance Determinants to Human Populations? A Systematic Review.
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DOI：
10.1089/fpd.2017.2411
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发表时间：
2018-08
影响因子：
2.8
通讯作者：
van Bunnik BAD
中科院分区：
文献类型：
--
作者：
Muloi D;Ward MJ;Pedersen AB;Fèvre EM;Woolhouse MEJ;van Bunnik BAD
农场动物在抗微生物药物耐药性细菌及其对人类的耐药性决定因素的出现和传播中所扮演的角色，人们知之甚少，并且存在争议。在这里，我们系统地回顾了当前的证据，表明食用动物是 AMR 向人类传播的原因。我们检索了 PubMed、Web of Science 和 EMBASE，查找 1940 年至 2016 年间发表的文献。我们的结果显示，8 项研究 (18%) 提出了 AMR 从食用动物传播到人类的证据，25 项研究 (56%) 表明存在动物和人类之间的传播，但没有明确方向，12 项研究 (26%) 不支持传播。纳入研究的证据质量各不相同；一项研究 (2%) 使用高分辨率打字工具，36 项研究 (80%) 使用中等分辨率打字工具，六项研究 (13%) 依赖低分辨率打字工具，两项研究 (5%) 基于阻力共现的结论。虽然一些研究建议提供证据证明抗菌素耐药性可能从食用动物传播到人类，但由于研究方法的限制，无法得出关于传播方向性的可靠结论。我们的研究结果强调需要将高分辨率基因组数据分析与系统收集的流行病学证据相结合，以重建食用动物和人类之间的 AMR 传播模式。
The role of farm animals in the emergence and dissemination of both AMR bacteria and their resistance determinants to humans is poorly understood and controversial. Here, we systematically reviewed the current evidence that food animals are responsible for transfer of AMR to humans. We searched PubMed, Web of Science, and EMBASE for literature published between 1940 and 2016. Our results show that eight studies (18%) suggested evidence of transmission of AMR from food animals to humans, 25 studies (56%) suggested transmission between animals and humans with no direction specified and 12 studies (26%) did not support transmission. Quality of evidence was variable among the included studies; one study (2%) used high resolution typing tools, 36 (80%) used intermediate resolution typing tools, six (13%) relied on low resolution typing tools, and two (5%) based conclusions on co-occurrence of resistance. While some studies suggested to provide evidence that transmission of AMR from food animals to humans may occur, robust conclusions on the directionality of transmission cannot be drawn due to limitations in study methodologies. Our findings highlight the need to combine high resolution genomic data analysis with systematically collected epidemiological evidence to reconstruct patterns of AMR transmission between food animals and humans.
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影响因子：
4.4
作者：
Hu, Yan-Yan;Cai, Jia-Chang;Chen, Gong-Xiang
通讯作者：
Chen, Gong-Xiang
影响因子：
14.2
作者：
Dohmen, W.;Bonten, M. J. M.;Heederik, D. J. J.
通讯作者：
Heederik, D. J. J.
影响因子：
4.5
作者：
de Been M;Lanza VF;de Toro M;Scharringa J;Dohmen W;Du Y;Hu J;Lei Y;Li N;Tooming-Klunderud A;Heederik DJ;Fluit AC;Bonten MJ;Willems RJ;de la Cruz F;van Schaik W
通讯作者：
van Schaik W
影响因子：
3.7
作者：
Dahms C;Hübner NO;Kossow A;Mellmann A;Dittmann K;Kramer A
通讯作者：
Kramer A
影响因子：
2.8
作者：
Jakobsen, Lotte;Kurbasic, Azra;Hammerum, Anette M.
通讯作者：
Hammerum, Anette M.