High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome.
High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome.
复制标题
DOI：
10.1186/1475-2891-9-55
复制
发表时间：
2010-11-22
影响因子：
5.4
通讯作者：
Atkin SL
中科院分区：
文献类型：
--
作者：
Sathyapalan T;Beckett S;Rigby AS;Mellor DD;Atkin SL
巧克力富含类黄酮，已被证明对包括心血管疾病和癌症在内的各种疾病都有好处。富含多酚的巧克力对慢性疲劳综合征(CFS)患者的影响之前还没有研究过。我们进行了一项双盲、随机、临床试点交叉研究，比较了高可可液/富含多酚巧克力(HCL/PR)和模拟等热量巧克力(无可可液/低多酚(CLF/LP))对慢性疲劳综合征受试者的疲劳和残余功能的影响。CFS患者在Chalder疲劳量表上至少有10分(满分11分)的严重疲劳。受试者接受以HCL/PR或CLF/LP形式进行的8周干预，其中2周为洗涤期，随后是用其他巧克力进行的8周干预。有10名受试者参加了这项研究。服用HCL/PR巧克力臂8周后Chalder疲劳量表评分显著改善[精确签名中位数(范围)]。(2-尾)][33(25-38)比21.5(6-35)0.01]，但当受试者被给予模拟等热量巧克力(CLF/CP)时，这种情况显著恶化[28.5(17-20)比34.5(13-26)0.03]。伦敦残障量表评估的残馀功能在接受HCL/PR臂治疗后也有显著改善[0.49(0.33-0.62)比0.64(0.44-0.83)0.01]，而在等热量巧克力治疗后恶化[00.44(0.43-0.68)比0.36(0.33-0.62)0.03]。同样，医院焦虑和抑郁评分在接受HCL/PR治疗后也有所改善，但在CLF/CP治疗后恶化。平均体重在整个试验过程中保持不变。这项研究表明，HCL/PR巧克力可能会改善慢性疲劳综合征患者的症状。
Chocolate is rich in flavonoids that have been shown to be of benefit in disparate conditions including cardiovascular disease and cancer. The effect of polyphenol rich chocolate in subjects with chronic fatigue syndrome (CFS) has not been studied previously. We conducted a double blinded, randomised, clinical pilot crossover study comparing high cocoa liquor/polyphenol rich chocolate (HCL/PR) in comparison to simulated iso-calorific chocolate (cocoa liquor free/low polyphenols(CLF/LP)) on fatigue and residual function in subjects with chronic fatigue syndrome. Subjects with CFS having severe fatigue of at least 10 out of 11 on the Chalder Fatigue Scale were enrolled. Subjects had either 8 weeks of intervention in the form of HCL/PR or CLF/LP, with a 2 week wash out period followed by 8 weeks of intervention with the other chocolate. Ten subjects were enrolled in the study. The Chalder Fatigue Scale score improved significantly after 8 weeks of the HCL/PR chocolate arm [median (range) Exact Sig. (2-tailed)] [33 (25 - 38) vs. 21.5 (6 - 35) 0.01], but that deteriorated significantly when subjects were given simulated iso-calorific chocolate (CLF/CP) [ 28.5 (17 - 20) vs. 34.5 (13-26) 0.03]. The residual function, as assessed by the London Handicap scale, also improved significantly after the HCL/PR arm [0.49 (0.33 - 0.62) vs. 0.64 (0.44 - 0.83) 0.01] and deteriorated after iso-calorific chocolate [00.44 (0.43 - 0.68) vs. 0.36 (0.33 - 0.62)0.03]. Likewise the Hospital Anxiety and Depression score also improved after the HCL/PR arm, but deteriorated after CLF/CP. Mean weight remained unchanged throughout the trial. This study suggests that HCL/PR chocolate may improve symptoms in subjects with chronic fatigue syndrome.
登录
查看更多内容
影响因子：
2.5
作者：
Vecchiet, J;Cipollone, F;Giamberardino, MA
通讯作者：
Giamberardino, MA
DOI：
10.1093/qjmed/90.3.223
发表时间：
1997-03-01
期刊：
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
影响因子：
--
作者：
Joyce, J;Hotopf, M;Wessely, S
通讯作者：
Wessely, S
影响因子：
--
作者：
HERTOG, MGL;KROMHOUT, D;KATAN, MB
通讯作者：
KATAN, MB
影响因子：
--
作者：
Keli, SO;Hertog, MGL;Kromhout, D
通讯作者：
Kromhout, D
影响因子：
4.2
作者：
Dillinger, TL;Barriga, P;Grivetti, LE
通讯作者：
Grivetti, LE