The role of metal components in the cardiovascular effects of PM2.5.
The role of metal components in the cardiovascular effects of PM2.5.
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DOI：
10.1371/journal.pone.0083782
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Qu Q
中科院分区：
文献类型：
--
作者：
Niu J;Liberda EN;Qu S;Guo X;Li X;Zhang J;Meng J;Yan B;Li N;Zhong M;Ito K;Wildman R;Liu H;Chen LC;Qu Q
暴露于环境细颗粒物（PM2.5）会增加心血管疾病（CVD）的风险。然而，机制和组件负责的影响知之甚少。基于我们先前的小鼠暴露研究，在中国金昌和张掖的女性居民中进行了一项转化的初步研究，以验证PM2.5的特定化学成分是PM2.5相关CVD的原因的假设。在这两个城市测量了PM2.5和35元素的日常环境和个人暴露。共招募了60名健康的非吸烟成年女性居民进行炎症生物标志物的测量。此外，还测量了20名受试者的循环内皮祖细胞（CEPC）。金昌和张掖的PM2.5水平相当（分别为47.4和54.5微克/立方米）。然而，金昌市的镍、铜、砷和硒含量分别是张掖市的82、26、12和6倍。金昌地区C-反应蛋白（3.44±3.46 vs.1.55 ±1.13）、白细胞介素-6（1.65±1.17 vs.1.09 ±0.60）和血管内皮生长因子（117.6±217.0 vs.22.7 ±21.3）水平显著高于其他地区。金昌地区受试者CEPCs各表型均显著低于张掖地区受试者。这些结果表明，特定的金属可能是PM2.5引起的心血管效应的重要组成部分，内皮修复能力的降低可能起着关键作用。
Exposure to ambient fine particulate matter (PM2.5) increases risks for cardiovascular disorders (CVD). However, the mechanisms and components responsible for the effects are poorly understood. Based on our previous murine exposure studies, a translational pilot study was conducted in female residents of Jinchang and Zhangye, China, to test the hypothesis that specific chemical component of PM2.5 is responsible for PM2.5 associated CVD. Daily ambient and personal exposures to PM2.5 and 35 elements were measured in the two cities. A total of 60 healthy nonsmoking adult women residents were recruited for measurements of inflammation biomarkers. In addition, circulating endothelial progenitor cells (CEPCs) were also measured in 20 subjects. The ambient levels of PM2.5 were comparable between Jinchang and Zhangye (47.4 and 54.5µg/m3, respectively). However, the levels of nickel, copper, arsenic, and selenium in Jinchang were 82, 26, 12, and 6 fold higher than Zhangye, respectively. The levels of C-reactive protein (3.44±3.46 vs. 1.55±1.13), interleukin-6 (1.65±1.17 vs. 1.09±0.60), and vascular endothelial growth factor (117.6±217.0 vs. 22.7±21.3) were significantly higher in Jinchang. Furthermore, all phenotypes of CEPCs were significantly lower in subjects recruited from Jinchang than those from Zhangye. These results suggest that specific metals may be important components responsible for PM2.5-induced cardiovascular effects and that the reduced capacity of endothelial repair may play a critical role.
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