Relationships between osteocalcin, glucose metabolism, and adiponectin in obese children: Is there crosstalk between bone tissue and glucose metabolism?
Relationships between osteocalcin, glucose metabolism, and adiponectin in obese children: Is there crosstalk between bone tissue and glucose metabolism?
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DOI：
10.4274/jcrpe.831
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发表时间：
2012-12
影响因子：
1.9
通讯作者：
Öçal G
中科院分区：
文献类型：
--
作者：
Abseyi N;Şıklar Z;Berberoğlu M;Hacıhamdioğlu B;Savaş Erdeve Ş;Öçal G
目的：最近，科学的兴趣集中在骨钙素，它来源于骨骼系统，和葡萄糖代谢之间的关联。虽然脂代谢、脂联素和代谢综合征之间的关系是众所周知的，但肥胖、胰岛素抵抗和骨钙素之间的关系在儿童中尚未阐明。本研究的目的是评估肥胖儿童和青少年胰岛素抵抗的患病率，以及调查脂联素和骨钙素对代谢综合征和胰岛素抵抗的影响。方法：共150名年龄在5 - 18岁之间的肥胖非糖尿病儿童和青少年被纳入研究。测定血清脂联素、骨钙素和胰岛素水平，并研究代谢综合征组分与脂联素和骨钙素水平的关系。采用稳态模型胰岛素抵抗指数（HOMA-IR）评价胰岛素抵抗。结果：28%的病例被确定为代谢综合征，年龄均大于10岁。在胰岛素抵抗、代谢综合征参数和骨钙素水平之间没有发现显著的相关性。代谢综合征、高胰岛素血症和血脂异常患者的脂联素水平显著降低。未发现脂联素和骨钙素水平之间存在显着相关性。结论：我们未能显示骨钙素对肥胖儿童和青少年胰岛素抵抗的影响。这一发现可能是由于缺乏高血糖的血糖水平在我们的情况下。 利益冲突：未声明。
Objective: Recently, scientific interest has focused on the association between osteocalcin, which originates from the skeletal system, and glucose metabolism. Although the association between lipid metabolism, adiponectin, and metabolic syndrome is well known, that between obesity, insulin resistance, and osteocalcin have not been clarified yet in children. The aim of this study was to assess the prevalence of insulin resistance in obese children and adolescents, as well as to investigate the effects of adiponectin and osteocalcin on the development of metabolic syndrome and insulin resistance. Methods: A total of 150 obese nondiabetic children and adolescents, aged between 5 and 18 years, were included in the study. Serum adiponectin, osteocalcin and insulin levels were measured, and the association of the components of metabolic syndrome with adiponectin and osteocalcin levels was investigated. Insulin resistance was evaluated by Homeostasis model assessment insulin resistance (HOMA-IR). Results: Metabolic syndrome was identified in 28% of the cases, all older than 10 years of age. No significant association was identified between insulin resistance, metabolic syndrome parameters, and osteocalcin levels. Adiponectin levels were significantly low in cases with metabolic syndrome, hyperinsulinemia, and in those with dyslipidemia. No significant association was found between adiponectin and osteocalcin levels. Conclusions: We failed to show the effect of osteocalcin on insulin resistance in obese children and adolescents. This finding may be due to absence of hypergycemic blood glucose levels in our cases. Conflict of interest:None declared.
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影响因子：
4
作者：
Hwang, Y-C.;Jeong, I-K.;Ahn, K-J.;Chung, H-Y.
通讯作者：
Chung, H-Y.
影响因子：
4.1
作者：
Kanazawa, Ippei;Yamaguchi, Toru;Sugimoto, Toshitsugu
通讯作者：
Sugimoto, Toshitsugu
影响因子：
4.2
作者：
Paldanius, P. M.;Ivaska, K. K.;Makitie, O.
通讯作者：
Makitie, O.
影响因子：
64.5
作者：
Lee, Na Kyung;Sowa, Hideaki;Karsenty, Gerard
通讯作者：
Karsenty, Gerard
影响因子：
5.8
作者：
Pittas, Anastassios G.;Harris, Susan S.;Dawson-Hughes, Bess
通讯作者：
Dawson-Hughes, Bess