Effect of pharmacotherapy for anxiety disorders on quality of life: a meta-analysis.
Effect of pharmacotherapy for anxiety disorders on quality of life: a meta-analysis.
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DOI：
10.1007/s11136-013-0573-8
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发表时间：
2014-05
影响因子：
3.5
通讯作者：
Sturm, Jamie
中科院分区：
文献类型：
--
作者：
Hofmann, Stefan G.;Wu, Jade Q.;Boettcher, Hannah;Sturm, Jamie
药物治疗是治疗焦虑症的有效方法，但它对生活质量的影响还没有得到系统的研究。我们的目标是进行药物干预对DSM-IV焦虑症患者生活质量结果的影响大小分析。使用PubMed、SqucINFO和Cochrane图书馆进行手动和电子搜索，以获取从第一个可用日期到2013年5月1日的记录，以进行焦虑症患者的药物干预试验，这些试验包括治疗前后的生活质量测量。在1865个条目中，93项研究被确定为潜在相关，32项符合纳入标准，其中22项研究的结果被检查，这些研究报告了27项不同的药理学试验，代表了4344名焦虑症患者的数据。数据由多个观察者独立提取，以估计组内和安慰剂对照的治疗变化对生活质量的随机影响。我们假设药物治疗可以改善生活质量，这与焦虑症状的改善有关。药物干预有效地改善了从治疗前到治疗后的生活质量(赫奇斯的g=.59)，尽管在那些使用安慰剂干预的试验中，受控效应规模较小(赫奇斯的g=.32)。这些效应大小是稳健的，随着出版年限的增加而增加，并随着焦虑症状的减少而增加。药物治疗对提高焦虑症患者的生活质量是有效的，症状的减少越多，生活质量的改善越大。
Pharmacotherapy is an effective treatment for anxiety disorders, but its effects on quality of life have not been examined systematically. Our objective was to conduct an effect size analysis of pharmacological interventions on quality of life outcomes in patients with DSM-IV anxiety disorders. Manual and electronic searches using PubMed, PsycINFO, and the Cochrane Library were conducted for records from the first available date through May 1st, 2013 for trials of pharmacological interventions in patients with anxiety disorders, which had measures of quality of life before and after treatment. Of 1,865 entries, 93 studies were identified as potentially relevant and 32 met inclusion criteria, of which results were examined from 22 studies reporting 27 distinct pharmacological trials, representing data from 4,344 anxiety disorder patients. Data were extracted independently by multiple observers to estimate within-group and placebo-controlled random effects of the treatment changes on quality of life. We hypothesized that pharmacotherapy improves quality of life, which is associated with improvement in anxiety symptoms. Pharmacological interventions effectively improved quality of life from before to after treatment (Hedges' g = .59), although the controlled effect size is smaller among those trials with placebo interventions (Hedges' g = .32). These effect sizes were robust, increased with publication year, and increased with reductions in anxiety symptoms. Pharmacological therapy is effective for improving quality of life in anxiety disorders, and larger symptom reductions are associated with greater improvement in quality of life.
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影响因子：
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作者：
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