Identification and function of proteolysis regulators in seminal fluid.
Identification and function of proteolysis regulators in seminal fluid.
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DOI：
10.1002/mrd.22130
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发表时间：
2013-02
影响因子：
2.5
通讯作者：
Wolfner, Mariana F.
中科院分区：
文献类型：
--
作者：
LaFlamme, Brooke A.;Wolfner, Mariana F.
体内受精动物精液中的蛋白质影响交配雌性的许多反应，影响雄性和雌性的生育能力。在这些蛋白质中，高度代表性的一类是蛋白水解调节剂（蛋白酶及其抑制剂）。虽然蛋白水解调节剂现在已经确定在所有动物的精液中的精液蛋白质组学研究已经进行（以及其他几个物种，他们没有），一个统一的理解蛋白水解的重要性，男性受精成功和其他生殖过程尚未实现。在这篇综述中，我们提供了一个概述的蛋白水解调节剂在人类和果蝇，最全面的已知精液蛋白质组的两个物种的精液中的识别。我们还强调报告表明，在生殖和交配后的过程中，特定的蛋白水解调节剂的功能意义。最后，我们提出了广泛的建议，为今后的研究方向的作用，积极精液蛋白水解调节剂和他们的非活性同系物，另一类重要的精液蛋白。我们希望这篇综述有助于研究人员对精液中蛋白水解调节剂的功能意义进行协调研究。
Proteins in the seminal fluid of animals with internal fertilization effect numerous responses in mated females that impact both male and female fertility. Among these proteins is the highly represented class of proteolysis regulators (proteases and their inhibitors). Though proteolysis regulators have now been identified in the seminal fluid of all animals in which proteomic studies of the seminal fluid have been conducted (as well as several other species in which they have not), a unified understanding of the importance of proteolysis to male fertilization success and other reproductive processes has not yet been achieved. In this review, we provide an overview of the identification of proteolysis regulators in the seminal fluid of humans and Drosophila melanogaster, the two species with the most comprehensively known seminal fluid proteomes. We also highlight reports demonstrating the functional significance of specific proteolysis regulators in reproductive and post-mating processes. Finally, we make broad suggestions for the direction of future research into the roles of both active seminal fluid proteolysis regulators and their inactive homologs, another significant class of seminal fluid proteins. We hope that this review aids researchers in pursuing a coordinated study of the functional significance of proteolysis regulators in semen.
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影响因子：
14.2
作者：
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通讯作者：
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通讯作者：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
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