Magnetoresponsive Functionalized Nanocomposite Aggregation Kinetics and Chain Formation at the Targeted Site during Magnetic Targeting.
Magnetoresponsive Functionalized Nanocomposite Aggregation Kinetics and Chain Formation at the Targeted Site during Magnetic Targeting.
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DOI：
10.3390/pharmaceutics14091923
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发表时间：
2022-09-12
期刊：
影响因子：
5.4
通讯作者：
Bernad ES
中科院分区：
文献类型：
--
作者：
Bernad SI;Socoliuc V;Susan-Resiga D;Crăciunescu I;Turcu R;Tombácz E;Vékás L;Ioncica MC;Bernad ES
血管疾病的药物治疗已被推广到抑制动脉粥样硬化斑块中的血管生成和预防外科干预后的再狭窄。本文研究了PEG功能化的磁性纳米复合材料团簇（PEG_MNCs）在局部递送后在动脉支架模型中的沉积和分布，以及PEG_MNCs在植入支架内和周围的聚集或链形成。中心概念是采用一个外部永磁体系统，其产生足够的磁场来磁化和引导支架动脉区域中的磁性纳米团簇。在室温（25 °C）下，在外部磁场中进行悬浮液模型的聚集过程的光学显微镜检查。根据光学显微镜照片，当存在外部磁场时，由于偶极磁相互作用，PEG_MNC颗粒形成长的线性聚集体。在磁性颗粒靶向过程中，通过注射泵以平均流速（流速为Um = 0.25 m/s，对应于Re = 232的雷诺数）将20 mL模型悬浮液注入（以39.6 mL/min的恒定流速持续30 s的时间）支架动脉模型。PEG_MNC簇被磁力（由永久外部磁铁产生）吸引，并在植入支架之前和内部捕获在支架支柱和底部动脉壁周围。通过计算静电排斥能、货车范德华能和磁偶极-偶极能，研究了MNC团簇间的胶体相互作用。目前的工作提供了必要的细节PEG_MNCs的聚集和链结构的发展，在外部磁场的存在下，这种结构形成的过程。
Drug therapy for vascular disease has been promoted to inhibit angiogenesis in atherosclerotic plaques and prevent restenosis following surgical intervention. This paper investigates the arterial depositions and distribution of PEG-functionalized magnetic nanocomposite clusters (PEG_MNCs) following local delivery in a stented artery model in a uniform magnetic field produced by a regionally positioned external permanent magnet; also, the PEG_MNCs aggregation or chain formation in and around the implanted stent. The central concept is to employ one external permanent magnet system, which produces enough magnetic field to magnetize and guide the magnetic nanoclusters in the stented artery region. At room temperature (25 °C), optical microscopy of the suspension model’s aggregation process was carried out in the external magnetic field. According to the optical microscopy pictures, the PEG_MNC particles form long linear aggregates due to dipolar magnetic interactions when there is an external magnetic field. During magnetic particle targeting, 20 mL of the model suspensions are injected (at a constant flow rate of 39.6 mL/min for the period of 30 s) by the syringe pump in the mean flow (flow velocity is Um = 0.25 m/s, corresponding to the Reynolds number of Re = 232) into the stented artery model. The PEG_MNC clusters are attracted by the magnetic forces (generated by the permanent external magnet) and captured around the stent struts and the bottom artery wall before and inside the implanted stent. The colloidal interaction among the MNC clusters was investigated by calculating the electrostatic repulsion, van der Waals and magnetic dipole-dipole energies. The current work offers essential details about PEG_MNCs aggregation and chain structure development in the presence of an external magnetic field and the process underlying this structure formation.
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影响因子：
5.4
作者：
Garello, Francesca;Svenskaya, Yulia;Parakhonskiy, Bogdan;Filippi, Miriam
通讯作者：
Filippi, Miriam
影响因子：
3.9
作者：
Sella, Gal;Gandelman, Gera;Teodorovich, Nicholay;Tuvali, Ortal;Ayyad, Omar;Abu Khadija, Haitham;Haberman, Dan;Poles, Lion;Jonas, Michael;Volodarsky, Igor;George, Jacob;Blatt, Alex
通讯作者：
Blatt, Alex
影响因子：
19
作者：
Kappes, Mona;Friedrich, Bernhard;Janko, Christina
通讯作者：
Janko, Christina
影响因子：
2.7
作者：
Dutz, Silvio;Clement, Joachim H.;Zeisberger, Matthias
通讯作者：
Zeisberger, Matthias
影响因子：
5.4
作者：
George, Thomashire A.;Hsu, Chuan-Chih;Meeson, Annette;Lundy, David J.
通讯作者：
Lundy, David J.