Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents.

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents.
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用于生物制剂磁靶向递送的微/纳米系统

DOI:
10.3390/pharmaceutics14061132
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发表时间:
2022-05-26
期刊:
影响因子:
5.4
通讯作者:
Filippi, Miriam
Filippi, Miriam
中科院分区:
医学2区
文献类型:
--
作者:
Garello, Francesca;Svenskaya, Yulia;Parakhonskiy, Bogdan;Filippi, Miriam

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药物的靶向递送有望有效治疗疾病并减少不良反应。具有强磁动量的纳米或微结构磁性材料可以通过生物体内的磁力进行无创控制。这些磁性载体为控制不同类型的生物制剂在人体中的输送开辟了前景,包括小分子、核酸和细胞。在本文中,我们描述了不同类型的磁性载体作为药物递送平台,并展示了不同的方法将其应用于生物制剂的磁性靶向递送。我们讨论了纳米/微系统或标记细胞注射到体循环或组织中的磁引导;然后,我们强调了组织工程中的新兴应用,最后,我们展示了磁靶向如何与成像技术相结合,以帮助药物输送。
Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects. Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. In the present review, we describe different types of magnetic carriers that can serve as drug delivery platforms, and we show different ways to apply them to magnetic targeted delivery of bioagents. We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and finally, we show how magnetic targeting can integrate with imaging technologies that serve to assist drug delivery.
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