Pulse electrical arc stimulator based on single-electrode for active exercise in tail-suspension rat
Pulse electrical arc stimulator based on single-electrode for active exercise in tail-suspension rat
复制标题
基于单电极的脉冲电弧刺激器用于悬尾大鼠主动运动
DOI：
10.1007/s11771-008-0492-y
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Xie Tian
中科院分区：
文献类型：
--
作者：
Sun Lian-wen;Yang Xiao;Zhang Xiao-wei;Sun Yao;Fan Yu-bo;Xie Tian
为了使大鼠进行主动运动以抵消大鼠尾悬模型的骨质流失，设计了一种基于单电极的低电流高压脉冲电刺激器。刺激器由单片机（单片机）控制，能精确控制刺激持续时间和刺激间隔，当记录的刺激次数达到程序设定的数值后停止运行。借助姿态估计部分，装置根据大鼠肢体的姿态，判断是否进行刺激，实现智能操作。开发了操作人员用计算机控制刺激器、保存实验数据和打印实验报告的软件。在实际实验中，通过刺激器产生电弧线，冲击大鼠的大鱼际。这引起大鼠疼痛，大鼠会主动收缩后肢以逃避疼痛，因此进行主动运动。尾悬大鼠每天训练2次，连续训练14 d。第0、14天采用双能x线吸收仪（DXA）测定大鼠股骨骨密度。结果表明，脉冲电弧刺激器刺激的主动运动可以减弱失重所致的骨质流失，该装置是一种方便的稳定性能电刺激器，可以肯定地诱导大鼠后肢进行主动运动。
To make rat do active exercise to counteract bone loss in the rat tail-suspension model, a pulse electrical stimulator based on single-electrode with a low-current and a high-voltage was designed. The stimulator was controlled by SCM (single chip micyoco) that could accurately control the stimulation duration and the interval between stimulations, and cease the operation after the recorded number of stimulation had reached the value set by the program. With the help of posture estimation part, the device would operate intelligently by determining whether to stimulate or not, depending on the posture of rat’s limb. Software was developed to make operator control the stimulator using computer, save the experiment data and print the report. In practical experiment, the voltaic arc is generated by the stimulator, and impacted on the rat’s thenar. This induced pain to the rat and the rat would actively contract its hindlimb to evade the pain, so active exercise was carried out. The tail-suspension rats were trained twice every day for 14 d. At the 0 and 14th day, bone mineral density of rat femurs was determined by dual energy X-ray absorptiometry (DXA). The results show that the active exercise stimulated by the pulse electrical arc stimulator can attenuate weightlessness-induced bone loss, and this device is a convenient steady performance electrical stimulator that can surely induce rat’s hindlimb to do active exercise.
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影响因子：
--
作者：
T. Liu;Zhen-bin Peng;Jin-tian Han
通讯作者：
T. Liu;Zhen-bin Peng;Jin-tian Han
影响因子：
4.2
作者：
G. D. Whedon
通讯作者：
G. D. Whedon
影响因子：
--
作者：
YEH, JK;LIU, CC;ALOIA, JF
通讯作者：
ALOIA, JF
DOI：
--
发表时间：
2005
期刊：
China Sport Science
影响因子：
--
作者：
Bum-Ho Bin
通讯作者：
Bum-Ho Bin
影响因子：
4.2
作者：
J. Yeh;J. Aloia;J. Tierney;S. Sprintz
通讯作者：
J. Yeh;J. Aloia;J. Tierney;S. Sprintz