Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis.
Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis.
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DOI：
10.1111/prd.12427
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发表时间：
2022-06
影响因子：
18.6
通讯作者：
Sahingur, Sinem E.
中科院分区：
文献类型：
--
作者：
Albuquerque-Souza, Emmanuel;Sahingur, Sinem E.
关键词：
肝脏具有广泛的功能，从控制代谢物、储存营养物质、解毒到免疫监控。虽然炎症对于组织重塑和维持体内平衡和正常的肝脏生理是必不可少的，但持续暴露于饮食和微生物产品为可能延长免疫激活和敏感宿主中未解决的炎症创造了一个利基环境。未能抑制炎症会导致慢性肝病的发展，其特征是纤维化、肝硬变，最终导致肝功能衰竭。肝脏与许多器官保持着密切的相互作用，这会影响其新陈代谢和生理。众所周知，口腔微环境可以影响其他器官的生理状况，新出现的证据表明，肝脏也可能如此。慢性炎症和微生物区系失调是导致牙周炎和慢性肝病(CLDs)临床病理的共同特征。事实上，已知的慢性牙周炎似乎与牙周炎有一定的关系，牙周炎在双向串扰中影响这些条件的开始或进展。在这篇综述中，我们探讨了以牙周炎为重点的口腔-肠道-肝脏轴与常见慢性低密度脂蛋白之间的联系，包括非酒精性脂肪性肝病、慢性病毒性肝炎、肝硬变和肝细胞癌。我们重点介绍了免疫途径和口腔微生物组的相互作用，它们可以联系口腔和肝脏健康，并为未来的研究提供了展望。
The liver carries out a wide range of functions ranging from the control of metabolites, nutrient storage, and detoxification to immunosurveillance. While inflammation is essential for the tissue remodeling and maintenance of homeostasis and normal liver physiology, constant exposure to dietary and microbial products creates a niche for potentially prolonged immune activation and unresolved inflammation in susceptible host. Failure to restrain inflammation can lead to development of chronic liver diseases characterized by fibrosis, cirrhosis and eventually liver failure. The liver maintains close interactions with numerous organs which can influence its metabolism and physiology. It is also known that oral cavity microenvironment can influence the physiological conditions of other organs and emerging evidence implicates that this could be true for the liver as well. Presence of chronic inflammation and dysbiotic microbiota is a common feature leading to clinical pathology both in periodontitis and chronic liver diseases (CLDs). In fact, known CLDs appear to have some relationship with periodontitis, which impacts the onset or progression of these conditions in a bidirectional crosstalk. In this review, we explore the emerging association between oral‐gut‐liver axis focusing on periodontitis and common CLDs including nonalcoholic fatty liver disease, chronic viral hepatitis, liver cirrhosis, and hepatocellular cancer. We highlight the immune pathways and oral microbiome interactions which can link oral cavity and liver health and offer perspectives for future research.
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影响因子：
3.7
作者：
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