ABO Blood Groups Do Not Predict Schistosoma mansoni Infection Profiles in Highly Endemic Villages of Uganda.
ABO Blood Groups Do Not Predict Schistosoma mansoni Infection Profiles in Highly Endemic Villages of Uganda.
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DOI：
10.3390/microorganisms9122448
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发表时间：
2021-11-27
期刊：
影响因子：
4.5
通讯作者：
Lamberton PHL
中科院分区：
文献类型：
--
作者：
Francoeur R;Atuhaire A;Arinaitwe M;Adriko M;Ajambo D;Nankasi A;Babayan SA;Lamberton PHL
曼氏血吸虫是一种引起严重公共卫生问题的寄生虫，全球有超过 2.4 亿人感染。仅在乌干达，就有大约 1160 万人受到影响。尽管该国进行了十多年的大规模药物管理，但高流行热点仍然存在，并且观察到反复严重且迅速再次感染的个体。由于宿主抗体和致病抗原之间的交叉反应，已知人类血型抗原在多种疾病的感染风险中发挥作用。关于血型对血吸虫病感染和病理学的影响存在相互矛盾的结果。此外，血型作为潜在的内在宿主因素对曼氏沙门氏菌患病率、强度、清除率、再感染动态以及合并感染风险的影响仍不清楚。因此，在乌干达的三个高流行社区评估了宿主血型与曼氏沙门氏菌感染动态之间的流行病学联系。使用包含重复治疗前曼氏沙门氏菌感染强度和清除率的纵向数据来分析学龄儿童血型之间的关联。土源性蠕虫合并感染状态和生物特征参数被纳入广义线性混合回归模型中，包括年龄、性别和体重指数（BMI），这些参数先前已被确定为影响血吸虫病患病率和强度的重要因素。分析显示，血型与曼氏沙门氏菌患病率、感染强度、清除率、再感染或合并感染之间没有关联。各个村庄的感染情况差异显着，鸡蛋负担随着年龄的增长而显着下降。虽然血型已被证明是多种疾病的预测因素，但本研究收集的数据表明，血型在这些高流行社区的曼氏沙门氏菌感染负担中并没有发挥重要作用。
Schistosoma mansoni is a parasite which causes significant public-health issues, with over 240 million people infected globally. In Uganda alone, approximately 11.6 million people are affected. Despite over a decade of mass drug administration in this country, hyper-endemic hotspots persist, and individuals who are repeatedly heavily and rapidly reinfected are observed. Human blood-type antigens are known to play a role in the risk of infection for a variety of diseases, due to cross-reactivity between host antibodies and pathogenic antigens. There have been conflicting results on the effect of blood type on schistosomiasis infection and pathology. Moreover, the effect of blood type as a potential intrinsic host factor on S. mansoni prevalence, intensity, clearance, and reinfection dynamics and on co-infection risk remains unknown. Therefore, the epidemiological link between host blood type and S. mansoni infection dynamics was assessed in three hyper-endemic communities in Uganda. Longitudinal data incorporating repeated pretreatment S. mansoni infection intensities and clearance rates were used to analyse associations between blood groups in school-aged children. Soil-transmitted helminth coinfection status and biometric parameters were incorporated in a generalised linear mixed regression model including age, gender, and body mass index (BMI), which have previously been established as significant factors influencing the prevalence and intensity of schistosomiasis. The analysis revealed no associations between blood type and S. mansoni prevalence, infection intensity, clearance, reinfection, or coinfection. Variations in infection profiles were significantly different between the villages, and egg burden significantly decreased with age. While blood type has proven to be a predictor of several diseases, the data collected in this study indicate that it does not play a significant role in S. mansoni infection burdens in these high-endemicity communities.
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DOI：
10.1093/cid/ciab679
发表时间：
2022-05-03
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.1
作者：
Haseeb, M. A.;Thors, C.;Eveland, L. K.
通讯作者：
Eveland, L. K.
影响因子：
3.2
作者：
Assare, Rufin K.;N'Tamon, Romeo N.;Utzinger, Juerg
通讯作者：
Utzinger, Juerg
影响因子：
4.7
作者：
AbdelMassih AF;Mahrous R;Taha A;Saud A;Osman A;Kamel B;Yacoub E;Menshawey E;Ismail HA;Aita L;Dous M;Saad M;AbdelAziz M;Zaghar M;Shebl N;El-Husseiny N;Fahmy N;Hegazy N;Khalid O;Saad O;Afdal P;Menshawey R;Husseiny R;Sherien S;Salama S;Gad S;Ali S;Maalim S;Ismail S;ElHefnawi Y;Aziz Y;Fouda R
通讯作者：
Fouda R
影响因子：
0.6
作者：
Arac, Esref;Solmaz, Ihsan;Demir, Cengiz
通讯作者：
Demir, Cengiz