The potential use of ABO blood group system for risk stratification of COVID-19.
The potential use of ABO blood group system for risk stratification of COVID-19.
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DOI：
10.1016/j.mehy.2020.110343
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发表时间：
2020-12
影响因子：
4.7
通讯作者：
Fouda R
中科院分区：
文献类型：
--
作者：
AbdelMassih AF;Mahrous R;Taha A;Saud A;Osman A;Kamel B;Yacoub E;Menshawey E;Ismail HA;Aita L;Dous M;Saad M;AbdelAziz M;Zaghar M;Shebl N;El-Husseiny N;Fahmy N;Hegazy N;Khalid O;Saad O;Afdal P;Menshawey R;Husseiny R;Sherien S;Salama S;Gad S;Ali S;Maalim S;Ismail S;ElHefnawi Y;Aziz Y;Fouda R
ABO血型是一种便宜且负担得起的检测方法，可以在诊断时立即从COVID-19患者中检索。越来越多的证据表明，非O型血型对COVID-19感染的易感性和严重程度都更高。这种关系背后的原因似乎难以捉摸。关于易感性，非O型个体具有抗A抗体，可以阻止病毒进入ACE-2受体，此外，非O型个体的自身免疫、高凝状态和生态失调风险较高，导致COVID-19血管炎性后遗症的趋势增加。我们可以得出结论，在诊断水平上，ABO血型可能用于受影响的COVID-19患者的风险分层，以预测并发症风险较高的患者的恶化。在治疗水平上，来自正常O型血个体的血浆可能潜在地取代用于治疗COVID-19的恢复期血清的使用。
ABO blood groups is a cheap and affordable test that can be immediately retrieved from COVID-19 patients at the diagnosis. There is increasing evidence that non-O blood groups have both higher susceptibility and higher severity of COVID-19 infections. The reason behind such relationship seems elusive. Regarding susceptibility, Non-O individuals have Anti-A antibodies which can prevent viral entry across ACE-2 receptors, moreover, Non-O individuals are at higher risk of autoimmunity, hypercoagulable state, and dysbiosis resulting in an augmented tendency for vascular inflammatory sequelae of COVID-19. We can conclude, on the diagnostic level, that ABO blood groups can be potentially used for risk stratification of affected COVID-19 patients, to anticipate the deterioration of patients at higher risk for complications. On a therapeutic level, plasma from normal O blood group individuals might potentially replace the use of convalescent serum for the treatment of COVID-19.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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