Emergence of nonmotor symptoms as the focus of research and treatment of Parkinson's disease: introduction to the special section on nonmotor dysfunctions in Parkinson's disease.
Emergence of nonmotor symptoms as the focus of research and treatment of Parkinson's disease: introduction to the special section on nonmotor dysfunctions in Parkinson's disease.
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非运动症状的出现是帕金森氏病研究和治疗的重点：帕金森氏病非运动功能障碍的特别部分。
DOI：
10.1037/a0032142
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发表时间：
2013-04
影响因子：
1.9
通讯作者：
Cronin-Golomb, Alice
中科院分区：
文献类型：
--
作者：
Cronin-Golomb, Alice
帕金森氏病(PD)的传统特征是以震颤、僵硬、运动迟缓以及姿势、步态和平衡障碍为主要运动症状。根据最近对神经病理阶段的理解，研究和治疗的一个相对较新的焦点是疾病的非运动性症状。在帕金森病的第一个运动体征出现之前，觉醒、情绪、睡眠和自主神经功能的紊乱会累及下部脑干，而下部脑干在黑质和多巴胺能系统之前就会受到影响。在疾病的后期，病理会延伸到大脑皮层，并伴随着认知和感知的损害。这一特别部分中的文章增进了我们对帕金森病非运动性症状的大脑基础的了解，包括视觉感知障碍、跨领域认知障碍以及精神和艺术表现。正在调查的亚型包括根据发病侧(左侧或右侧)、主要认知特征和性别描述的亚型。综上所述，这一特别部分中的文章反映了该领域对帕金森病的非运动性症状、其大脑基础以及相应的治疗潜力的日益关注。
Parkinson's disease (PD) is traditionally characterized by the cardinal motor symptoms of tremor, rigidity, slowness of movement, and impairments of posture, gait, and balance. A relatively new focus of research and treatment is the nonmotor symptoms of the disease, following from recent understanding of the neuropathological stages. Disruptions of arousal, mood, sleep, and autonomic function before the first motor signs of PD implicate the lower brainstem, which is affected before the substantia nigra and dopaminergic system. In later stages of the disease, the pathology extends to the cortex, accompanied by impairments in cognition and perception. The articles in this special section advance our knowledge of the brain bases of the nonmotor symptoms of PD, including disrupted visual perception, impaired cognition across a range of domains, and psychiatric and artistic manifestations. Subtypes under investigation include those described by side of disease onset (left or right body side), predominant cognitive profile, and gender. Taken together, the articles in this special section reflect the field's growing focus on the nonmotor symptoms of PD, their brain bases, and the corresponding potential for their treatment.
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