Effect of lidocaine with and without epinephrine on lymphatic contractile activity in mice in vivo.
Effect of lidocaine with and without epinephrine on lymphatic contractile activity in mice in vivo.
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DOI：
10.1007/s00540-016-2260-8
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发表时间：
2016-12
影响因子：
2.8
通讯作者：
Sevick-Muraca, Eva M.
中科院分区：
文献类型：
--
作者：
Kwon, Sunkuk;Sevick-Muraca, Eva M.
已知局部麻醉剂利多卡因注射到皮肤后会影响皮肤血流量。然而，尚不清楚是否真皮淋巴功能也会受到影响。因此，我们描述了淋巴功能对利多卡因加肾上腺素和不加肾上腺素的反应。采用皮内注射吲哚菁绿（ICG）的无创近红外荧光成像（NIRFI）来表征小鼠皮下注射2%利多卡因加1:10万肾上腺素或生理盐水后的淋巴“泵送”功能。在这些干预后立即进行10 - 20分钟，并在干预后1、3和5小时进行NIRFI。sc注射利多卡因后10min淋巴收缩频率显著降低，并在恢复基线前保持稳定5min。然而，在2%利多卡因中加入1:10万肾上腺素后，注射后5分钟淋巴收缩频率迅速增加，15分钟后恢复到基线水平。注射生理盐水后5min淋巴收缩频率增加，10min淋巴收缩频率恢复到基线水平。虽然利多卡因的使用显示淋巴功能的下降，但肾上腺素与利多卡因的结合导致了收缩活性增加的主要净效应。
A local anesthetic, lidocaine, is known to affect cutaneous blood flow when injected to the skin. However, it is unknown if dermal lymphatic function can also be affected. Therefore, we characterized lymphatic function in response to administration of lidocaine with and without epinephrine. Non-invasive near-infrared fluorescence imaging (NIRFI) with intradermal injection of indocyanine green (ICG) was used to characterize lymphatic “pumping” function in mice after subcutaneous injection of 2% lidocaine with and without 1:100,000 epinephrine or saline. NIRFI was performed for 10–20mins immediately after and 1, 3, and 5hrs after these interventions. Lymphatic contraction frequencies significantly decreased 10mins after s.c. injection of lidocaine and remained plateaued for another 5mins, before returning to baseline. However, addition of 1:100,000 epinephrine to 2% lidocaine rapidly increased lymphatic contraction frequencies at 5mins post-injection, which returned to baseline levels 15mins later. Injection of saline also increased lymphatic contraction frequency 5 mins after injection, which returned to baseline 10min post-injection. Although lidocaine administration showed a decrease in lymphatic function, the combination of epinephrine with lidocaine resulted in a predominant net effect of increased contractile activity.
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DOI：
10.1113/jphysiol.1965.sp007706
发表时间：
1965-01-01
期刊：
J PHYSIOL [LONDON]
影响因子：
--
作者：
HALL, J. G.;MORRIS, B.;WOOLLEY, G.
通讯作者：
WOOLLEY, G.
淋巴收缩性；淋巴管的可能内在机制用于淋巴的运输。
DOI：
10.1084/jem.90.5.497
发表时间：
1949-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
SMITH RO
通讯作者：
SMITH RO
影响因子：
9.8
作者：
Newton, DJ;McLeod, GA;Belch, JJF
通讯作者：
Belch, JJF
影响因子：
8.8
作者：
Hattori, J;Yamakage, M;Namiki, A
通讯作者：
Namiki, A
影响因子：
3.8
作者：
van Helden, Dirk F.;Thomas, Paul A.;Isbister, Geoffrey K.
通讯作者：
Isbister, Geoffrey K.