Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis.
Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis.
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DOI：
10.1111/vaa.12030
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发表时间：
2013-07
影响因子：
1.7
通讯作者：
Hammock BD
中科院分区：
文献类型：
--
作者：
Guedes AG;Morisseau C;Sole A;Soares JH;Ulu A;Dong H;Hammock BD
一匹被诊断为双侧前肢蹄叶炎和左前肢蜂窝织炎的4岁、500 kg纯种雌性马变得严重疼痛，并且对单独或与加巴喷丁联合（第6天和第7天）的非甾体抗炎治疗（第1、2、3和4天氟尼辛葡甲胺;第5、6和7天保泰松）无效。由三名个体使用视觉模拟量表（VAS; 0=无疼痛，10=最严重疼痛）独立评估的疼痛评分在第6天为8.5，在第7天增加至9.5。无创血压监测显示重度高血压。由于出于人道原因以及技术和财政限制考虑安乐死，因此决定在治疗方案中添加一种实验性新药反式-4-{4-[3-（4-三氟甲氧基-苯基）-脲基]-环己氧基}-苯甲酸（t-TUCB），其是可溶性环氧化物水解酶（sEH）的抑制剂。根据对马sEH的药物效力，选择给药剂量和频率，以产生2.5 μM至30 nM范围内的血浆浓度。t-TUCB给药后疼痛评分显著下降，血压逐渐降至生理正常值。每日测量的t-TUCB血浆浓度在预期范围内，而保泰松和加巴喷丁血浆水平低于建议的有效浓度。在t-TUCB给药期间和之后，未检测到对临床和实验室检查的不良影响。母马在治疗后的三个月内没有发生任何蹄叶炎。
A 4-year old, 500 kg Thoroughbred female horse diagnosed with bilateral forelimb laminitis and cellulitis on the left forelimb became severely painful and refractory to non-steroidal anti-inflammatory therapy (flunixin meglumine on days 1, 2, 3 and 4; and phenylbutazone on days 5, 6 and 7) alone or in combination with gabapentin (days 6 and 7). Pain scores assessed independently by three individuals with a visual analog scale (VAS; 0= no pain and 10=worst possible pain) were 8.5 on day 6, and it increased to 9.5 on day 7. Non-invasive blood pressure monitoring revealed severe hypertension. As euthanasia was being considered for humane reasons as well as technical and financial constraints, a decision was made to add an experimental new drug, trans-4-{4-[3-(4-Trifluoromethoxy-phenyl)-ureido]-cyclohexyloxy}-benzoic acid (t-TUCB), which is an inhibitor of soluble epoxide hydrolase (sEH), to the treatment protocol. Dose and frequency of administration were selected to produce plasma concentrations within the range of 2.5 μM and 30 nM based on the drug potency against equine sEH. Pain scores decreased sharply and remarkably following t-TUCB administration and blood pressure progressively decreased to physiologic normal values. Plasma concentrations of t-TUCB, measured daily, were within the expected range, whereas phenylbutazone and gabapentin plasma levels were below the suggested efficacious concentrations. No adverse effects were detected on clinical and laboratory examinations during and after t-TUCB administration. The mare did not get any episode of laminitis in the three months following the treatment.
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影响因子：
2.2
作者：
Belknap, J. K.;Giguere, S.;Pollitt, C. C.
通讯作者：
Pollitt, C. C.
DOI：
10.2460/javma.231.5.755
发表时间：
2007-09-01
影响因子：
1.9
作者：
Davis, Jennifer L.;Posner, Lysa P.;Elce, Yvonne
通讯作者：
Elce, Yvonne
DOI：
10.1111/j.1939-1676.1993.tb01012.x
发表时间：
1993-07-01
影响因子：
2.6
作者：
HOOD, DM;GROSENBAUGH, DA;THOMAS, BC
通讯作者：
THOMAS, BC
影响因子：
7.4
作者：
Jones, Emma;Vinuela-Fernandez, Ignacio;Fleetwood-Walker, Susan M.
通讯作者：
Fleetwood-Walker, Susan M.
影响因子：
5.7
作者：
Eckhardt, K;Ammon, S;Mikus, G
通讯作者：
Mikus, G