LED Phototherapy with Gelatin Sponge Promotes Wound Healing in Mice.
LED Phototherapy with Gelatin Sponge Promotes Wound Healing in Mice.
复制标题
LED 光疗与明胶海绵促进小鼠伤口愈合
DOI：
10.1111/php.12816
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发表时间：
2018-01
影响因子：
3.3
通讯作者：
Li T
中科院分区：
文献类型：
--
作者：
Zhang H;Liu S;Yang X;Chen N;Pang F;Chen Z;Wang T;Zhou J;Ren F;Xu X;Li T
发光二极管（LED）体积小但效率高，可用于为光疗设备等治疗设备提供动力，同时降低设备的尺寸要求。在这项研究中，设计了一种LED光疗设备，利用小鼠模型以及暴露于红光和蓝光的细胞系来研究其对伤口愈合可能产生的影响。为了加强伤口光疗，制作了一种明胶海绵。结果表明，红光和蓝光促进了细胞生长和伤口愈合，而带有明胶海绵的蓝光在伤口愈合的早期阶段保护伤口免受感染。因此，LED光疗设备与明胶海绵相结合在伤口愈合的临床应用中具有潜在意义。
设计了一种LED光疗设备，利用小鼠模型以及暴露于红光和蓝光的细胞系来检测其对伤口愈合可能产生的影响。为了加强伤口光疗，制作了一种明胶海绵并应用于伤口愈合。结果表明，红光和蓝光促进了细胞生长和伤口愈合，而带有明胶海绵的蓝光在伤口愈合的早期阶段保护伤口免受感染。因此，LED光疗设备与明胶海绵相结合在伤口愈合的临床应用中具有潜在意义。
Tiny but highly efficient, a light emitting diode (LED) can power a therapy device, such as a phototherapy device, and, at the same time, decrease the device’s size requirements. In this study, a LED phototherapy device was designed to investigate the possible impact on wound healing using a mouse model and a cell line exposed to red and blue light. To enhance wound phototherapy, a gelatin sponge was fabricated. Results showed that the red and blue lights promoted cell growth and wound healing, while the blue light with a gelatin sponge protected the wound from infection in the early stages of wound healing. The LED phototherapy device combined with the gelatin sponge, therefore, has potential significance in clinical application for wound healing. A LED phototherapy device was designed to detect the possible effects for wound healing using a mouse model and a cell line exposed to red and blue light. To enhance the wound phototherapy, a gelatin sponge was fabricated and applied to the wound healing. Results showed that the red and blue light promoted cell growth and wound healing, while the blue light with a gelatin sponge protected the wound from infection in the early stages of wound healing. The LED phototherapy device combined with the gelatin sponge, therefore, has potential significance in clinical application for wound healing.
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影响因子：
2.1
作者：
Basso FG;Pansani TN;Turrioni AP;Bagnato VS;Hebling J;de Souza Costa CA
通讯作者：
de Souza Costa CA
影响因子：
--
作者：
Cavalcanti de Sousa, Ana Paula;Santos, Jean N.;Pinheiro, Antonio L. B.
通讯作者：
Pinheiro, Antonio L. B.
影响因子：
64.8
作者：
Jin, HJ;Kaplan, DL
通讯作者：
Kaplan, DL
影响因子：
3.1
作者：
Ramalho, Karen M.;Luiz, Ana C.;Magalhaes, Marina Gallottini
通讯作者：
Magalhaes, Marina Gallottini
影响因子：
--
作者：
Colombo, Fabio;Neto, Alberto de Aguiar Pires Valenca;Reis, Silvia Regina de Almeida
通讯作者：
Reis, Silvia Regina de Almeida