Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
复制标题
DOI：
10.1016/j.cmet.2020.06.018
复制
发表时间：
2020-09-01
期刊：
影响因子：
29
通讯作者：
Varady, Krista A.
中科院分区：
文献类型：
--
作者：
Cienfuegos, Sofia;Gabel, Kelsey;Kalam, Faiza;Ezpeleta, Mark;Wiseman, Eric;Pavlou, Vasiliki;Lin, Shuhao;Oliveira, Manoela Lima;Varady, Krista A.
限时喂养（TRF）方案越来越受欢迎;然而，很少有研究检查其减肥效果。我们进行了第一项人体试验（Clinicaltrials. gov-NCT 03867773），以比较两种流行形式的TRF（4小时和6小时）对体重和心脏代谢风险因素的影响。肥胖成年人被随机分为4小时TRF（仅在下午3点至7点之间进食），6小时TRF（仅在下午1点至7点之间进食）或对照组（无进餐时间限制）。8周后，与对照组相比，4小时和6小时TRF产生了相当的体重减轻（约3%）、胰岛素抵抗和氧化应激。两个TRF组的能量摄入量均减少了550 kcal/d，不计算卡路里。这些发现表明，4小时和6小时TRF在8周内诱导体重轻度降低，并显示出作为体重减轻干预措施的前景。这些饮食也可以改善心脏代谢健康的某些方面。Cienfuegos等人比较了两种流行形式的限时喂养（4小时和6小时）对肥胖成人体重和心脏代谢风险因素的影响。两种饮食在体重、能量摄入、胰岛素抵抗和氧化应激方面都产生了相当的减少。
Time-restricted feeding (TRF) regimens have grown in popularity; however, very few studies have examined their weight loss efficacy. We conducted the first human trial (Clinicaltrials.gov - NCT03867773) to compare the effects of two popular forms of TRF (4-h and 6-h) on body weight and cardiometabolic risk factors. Adults with obesity were randomized to 4-h TRF (eating only between 3 to 7 pm), 6-h TRF (eating only between 1 to 7 pm) or a control group (no meal timing restrictions). After 8 weeks, 4-h and 6-h TRF produced comparable reductions in body weight (∼3%), insulin resistance and oxidative stress, versus controls. Energy intake was reduced by ∼550 kcal/d in both TRF groups, without calorie counting. These findings suggest that 4-h and 6-h TRF induce mild reductions in body weight over 8 weeks, and show promise as interventions for weight loss. These diets may also improve some aspects of cardiometabolic health. Cienfuegos et al. compared the effect of two popular forms of time-restricted feeding (4-h and 6-h) on body weight and cardiometabolic risk factors in adults with obesity. Both diets produced comparable reductions in body weight, energy intake, insulin resistance and oxidative stress.
登录
查看更多内容
影响因子：
5.9
作者：
Bowen J;Brindal E;James-Martin G;Noakes M
通讯作者：
Noakes M
影响因子：
2.7
作者：
Gayoso-Diz P;Otero-González A;Rodriguez-Alvarez MX;Gude F;García F;De Francisco A;Quintela AG
通讯作者：
Quintela AG
影响因子：
3.6
作者：
Antoni, Rona;Johnston, Kelly L.;Robertson, M. Denise
通讯作者：
Robertson, M. Denise
影响因子：
7.1
作者：
Das, Sai Krupa;Gilhooly, Cheryl H.;Roberts, Susan B.
通讯作者：
Roberts, Susan B.
影响因子：
64.8
作者：
Houstis, N;Rosen, ED;Lander, ES
通讯作者：
Lander, ES