Whole Genome Sequencing of Danish Staphylococcus argenteus Reveals a Genetically Diverse Collection with Clear Separation from Staphylococcus aureus.

Whole Genome Sequencing of Danish Staphylococcus argenteus Reveals a Genetically Diverse Collection with Clear Separation from Staphylococcus aureus.
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DOI:
10.3389/fmicb.2017.01512
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发表时间:
2017
影响因子:
5.2
通讯作者:
Westh H
Westh H
中科院分区:
生物学2区
文献类型:
--
作者:
Hansen TA;Bartels MD;Høgh SV;Dons LE;Pedersen M;Jensen TG;Kemp M;Skov MN;Gumpert H;Worning P;Westh H

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金黄色葡萄球菌(S. argenteus)是一种新鉴定的葡萄球菌属物种,其被错误鉴定为金黄色葡萄球菌(S.金黄色葡萄球菌),并且具有临床相关性。我们发现了25个S。在我们收集的全基因组测序的S.金黄色。将这些基因组与公开可用的基因组进行比较,结果显示七个簇对应于七个克隆复合体。S. argenteus与S.核心基因组分析表明,两个物种共有基因库的33%,同源性为90%。对移动的元件的评估显示,在S.银白色葡萄球菌和金黄色。该数据集强调S.银白色葡萄球菌和金黄色葡萄球菌是两个不同的物种,共享遗传物质。
Staphylococcus argenteus (S. argenteus) is a newly identified Staphylococcus species that has been misidentified as Staphylococcus aureus (S. aureus) and is clinically relevant. We identified 25 S. argenteus genomes in our collection of whole genome sequenced S. aureus. These genomes were compared to publicly available genomes and a phylogeny revealed seven clusters corresponding to seven clonal complexes. The genome of S. argenteus was found to be different from the genome of S. aureus and a core genome analysis showed that ~33% of the total gene pool was shared between the two species, at 90% homology level. An assessment of mobile elements shows flow of SCCmec cassettes, plasmids, phages, and pathogenicity islands, between S. argenteus and S. aureus. This dataset emphasizes that S. argenteus and S. aureus are two separate species that share genetic material.
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