“Structural imprinting” of the cutaneous immune effector function
“Structural imprinting” of the cutaneous immune effector function
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皮肤免疫效应功能的“结构印记”
DOI：
10.1080/21688370.2020.1851561
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发表时间：
2020
期刊：
影响因子：
3.1
通讯作者：
Ogawa Tatsuya
中科院分区：
文献类型：
--
作者：
Ishitsuka Yosuke;Roop Dennis R.;Ogawa Tatsuya
角化提供了对干燥的耐受性和机械耐久性。Loricrin是一种富含硫醇的表皮蛋白，能有效地稳定终末分化的角质形成细胞并维持氧化还原稳态。几十年前发现的无症状的loricrin基因敲除（LKO）表型是相当不可预测的。然而，当包括氧化还原驱动的nf - e2相关因子2介导的备份反应时，LKO小鼠提供了观察改变或“准正常”稳态的机会。具体来说，考虑到组织结构以及局部代谢传递免疫信号，我们试图从免疫学角度剖析表皮分化程序截断的后果。通过对综合证据的回顾，我们试图对外周免疫系统的调节产生一个综合的观点，这种调节可能发生在具有截断分化的鳞状上皮组织中。这种合成不仅可能提供角化的见解，而且还可能导致识别表皮固有的影响免疫效应功能的因素。
Keratinization provides tolerance to desiccation and mechanical durability. Loricrin, which is an epidermal thiol-rich protein, efficiently stabilizes terminally differentiated keratinocytes and maintains redox homeostasis. The discovery of the largely asymptomatic loricrin knockout (LKO) phenotype decades ago was rather unpredicted. Nevertheless, when including redox-driven, NF-E2-related factor 2-mediated backup responses, LKO mice provide opportunities for the observation of altered or “quasi-normal” homeostasis. Specifically, given that the tissue structure, as well as the local metabolism, transmits immunological signals, we sought to dissect the consequence of truncated epidermal differentiation program from immunological perspectives. Through a review of the aggregated evidence, we have attempted to generate an integrated view of the regulation of the peripheral immune system, which possibly occurs within the squamous epithelial tissue with truncated differentiation. This synthesis might not only provide insights into keratinization but also lead to the identification of factors intrinsic to the epidermis that imprint the immune effector function.
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影响因子：
11.8
作者：
Huebner, Aaron J.;Dai, Daisy;Morasso, Maria;Schmidt, Edward E.;Schaefer, Matthias;Werner, Sabine;Roop, Dennis R.
通讯作者：
Roop, Dennis R.
DOI：
10.1083/jcb.40.3.830
发表时间：
1969-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fukuyama K;Epstein WL
通讯作者：
Epstein WL
影响因子：
64.5
作者：
MEHREL, T;HOHL, D;ROOP, DR
通讯作者：
ROOP, DR
影响因子：
64.5
作者：
RICE, RH;GREEN, H
通讯作者：
GREEN, H
DOI：
10.1073/pnas.0507385102
发表时间：
2005-10-11
影响因子：
11.1
作者：
Li, M;Messaddeq, N;Chambon, P
通讯作者：
Chambon, P