Effects of smoking, gender and occupational exposure on the risk of severe pulmonary fibrosis: a population-based case-control study.
Effects of smoking, gender and occupational exposure on the risk of severe pulmonary fibrosis: a population-based case-control study.
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DOI：
10.1136/bmjopen-2013-004018
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发表时间：
2014-01-09
期刊：
影响因子：
2.9
通讯作者：
Torén K
中科院分区：
文献类型：
--
作者：
Ekström M;Gustafson T;Boman K;Nilsson K;Tornling G;Murgia N;Torén K
评估吸烟、性别和职业暴露对发生重度肺纤维化（PF）风险的影响，包括剂量反应和交互作用。1997年2月至2000年4月在瑞典对171例PF患者（病例）进行了长期氧疗，并对719例来自普通人群的随机对照参与者进行了国家病例对照研究。在这些病例中，137例可能患有特发性PF（IPF）。使用Mantel-Haenszel分析和条件Logistic回归估计吸烟、性别和职业暴露的OR，控制年龄和诊断年份。吸烟的不良影响因男性性别和职业暴露而放大，与非暴露女性相比，PF的OR为4.6（95% CI 2.1至10.3），IPF的OR为3.0（1.3至6.5）。较高的累积吸烟暴露与风险增加呈线性相关。与吸烟少于10包-年相比，吸烟≥20包-年与PF和IPF风险增加相关，OR分别为2.6（1.4至4.9）和2.5（1.3至5.0）。吸烟与严重PF风险增加有剂量相关性。有吸烟史和职业暴露史的男性是发生严重PF的特殊风险人群。
To estimate the effects of smoking, gender and occupational exposure on the risk of developing severe pulmonary fibrosis (PF), including dose-response and interaction effects. National case–control study of 171 patients (cases) who had started a long-term oxygen therapy for PF in Sweden between February 1997 and April 2000, and 719 random control participants from the general population. Of these cases, 137 had probable idiopathic PF (IPF). The ORs for smoking, gender and occupational exposure were estimated using Mantel-Haenszel analysis and conditional logistic regression, controlling for age and year of diagnosis. The adverse effect of smoking was amplified by male gender and occupational exposure, OR 4.6 (95% CI 2.1 to 10.3) for PF, and OR 3.0 (1.3 to 6.5) for IPF, compared with in non-exposed women. Higher cumulative smoking exposure was linearly associated with increased risks. Compared with smoking less than 10 pack-years, smoking ≥20 pack-years was associated with increased risk of PF and IPF, OR 2.6 (1.4 to 4.9) and OR 2.5 (1.3 to 5.0), respectively. Smoking has a dose-related association with increased risk of severe PF. Men with a history of smoking and occupational exposure is a particular risk group for developing severe PF.
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影响因子：
9.6
作者：
Mejia, Mayra;Carrillo, Guillermo;Selman, Moises
通讯作者：
Selman, Moises
影响因子：
4.3
作者：
Garcia-Sancho Figueroa, Ma. Cecilia;Carrillo, Guillermo;Selman, Moises
通讯作者：
Selman, Moises
影响因子：
6.9
作者：
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通讯作者：
Tanaka, H
影响因子：
5
作者：
Baumgartner, KB;Samet, JM;Waldron, JA
通讯作者：
Waldron, JA
DOI：
10.1164/rccm.2009-040gl
发表时间：
2011-03-15
影响因子：
24.7
作者：
Raghu, Ganesh;Collard, Harold R.;Schuenemann, Holger J.
通讯作者：
Schuenemann, Holger J.