The Impact of Visual Cues, Reward, and Motor Feedback on the Representation of Behaviorally Relevant Spatial Locations in Primary Visual Cortex.
The Impact of Visual Cues, Reward, and Motor Feedback on the Representation of Behaviorally Relevant Spatial Locations in Primary Visual Cortex.
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DOI：
10.1016/j.celrep.2018.08.010
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发表时间：
2018-09-04
期刊：
影响因子：
8.8
通讯作者：
Rochefort NL
中科院分区：
文献类型：
--
作者：
Pakan JMP;Currie SP;Fischer L;Rochefort NL
视觉刺激和运动反馈的整合对于成功的视觉导航至关重要。这些信号已经被证明可以以经验依赖的方式塑造初级视觉皮层（V1）中的神经元活动。在这里，我们研究了视觉，奖励和自我运动相关的输入是否被整合，以编码V1神经元中的行为相关位置。在虚拟环境中使用行为任务，当小鼠学会沿着沿着线性走廊定位奖励时，我们监测了第2/3层神经元的活动。通过学习，一部分神经元对预期的奖励位置做出反应。没有视觉线索的奖励位置，行为和神经元的反应依赖于自我运动衍生的估计。然而，当视觉线索可用时，神经元和行为反应都由视觉信息驱动。因此，一群V1神经元编码行为相关的空间位置，基于视觉线索或在视觉线索不存在时的自我运动反馈。大多数V1 L2/3神经元在学习奖励任务后表现出任务相关的活动。一个神经元子集对预期的奖励位置做出反应。没有视觉线索，行为和神经元反应依赖于自我运动信号。表明与行为任务相关的空间位置在初级视觉皮层中表示。对预期奖励位置的神经元和行为反应主要依赖于视觉信息。在没有视觉标志的情况下，神经元和行为反应都是由自我运动衍生的信息驱动的。
The integration of visual stimuli and motor feedback is critical for successful visually guided navigation. These signals have been shown to shape neuronal activity in the primary visual cortex (V1), in an experience-dependent manner. Here, we examined whether visual, reward, and self-motion-related inputs are integrated in order to encode behaviorally relevant locations in V1 neurons. Using a behavioral task in a virtual environment, we monitored layer 2/3 neuronal activity as mice learned to locate a reward along a linear corridor. With learning, a subset of neurons became responsive to the expected reward location. Without a visual cue to the reward location, both behavioral and neuronal responses relied on self-motion-derived estimations. However, when visual cues were available, both neuronal and behavioral responses were driven by visual information. Therefore, a population of V1 neurons encode behaviorally relevant spatial locations, based on either visual cues or on self-motion feedback when visual cues are absent. Most V1 L2/3 neurons show task-related activity after learning a rewarded task A subset of neurons became responsive to an expected reward location Without visual cues, behavioral and neuronal responses rely on self-motion signals With visual cues, behavioral and neuronal responses rely on visual information Pakan et al. show that spatial locations that are relevant for a behavioral task are represented in the primary visual cortex. Both neuronal and behavioral responses to an expected reward location primarily rely on visual information. Without visual landmarks, both neuronal and behavioral responses are driven by self-motion derived information.
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