A probabilistic model for the ultradian timing of REM sleep in mice.
A probabilistic model for the ultradian timing of REM sleep in mice.
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DOI：
10.1371/journal.pcbi.1009316
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发表时间：
2021-08
影响因子：
4.3
通讯作者：
Weber F
中科院分区：
文献类型：
--
作者：
Park SH;Baik J;Hong J;Antila H;Kurland B;Chung S;Weber F
哺乳动物睡眠的一个显着特征是快速眼动（REM）睡眠和非快速眼动（NREM）睡眠之间的交替。然而，这两个睡眠阶段如何相互影响并从而调节快速眼动睡眠发作的时间仍然很大程度上尚未解决。在这里，我们开发了一个统计模型，指定 REM 和随后的 NREM 睡眠之间的关系，以量化 REM 睡眠如何影响随后的 NREM 睡眠持续时间及其小鼠的电生理特征。我们表明，对数正态混合模型很好地描述了之前的 REM 睡眠持续时间如何影响 NREM 睡眠量，直到下一个 REM 睡眠周期。该模型支持两种不同类型的睡眠周期的存在：短周期形成紧密间隔的快速眼动睡眠序列，而在长周期中，快速眼动睡眠首先是一段非快速眼动睡眠，在此期间过渡到快速眼动睡眠的可能性极小。该不应期的特点是脑电图 (EEG) 的 θ 和 Sigma 范围功率较低、纺锤波频率较低和频繁的微唤醒，其持续时间随着之前的快速眼动睡眠持续时间按比例增加。使用我们的模型，我们估计了从非快速眼动睡眠过渡到快速眼动睡眠时的快速眼动睡眠倾向，发现进入快速眼动睡眠的倾向较高，导致快速眼动睡眠时间更长，脑电图功率降低。与浅色阶段相比，黑暗阶段快速眼动睡眠倾向的形成较慢。我们的数据驱动建模方法揭示了小鼠快速眼动睡眠发作的时间和持续时间的基本原理，并提供了一个灵活的框架来描述健康和疾病中快速眼动睡眠的超电调节。在睡眠期间，哺乳动物的大脑在两种大脑状态之间反复交替：快速眼动睡眠和非快速眼动睡眠。这种亚电振荡构成了一种基本的大脑节律，即所谓的睡眠周期，它在哺乳动物物种中是保守的。然而，产生睡眠周期的机制仍然很大程度上未知。哺乳动物睡眠的一个保守的统计特征是快速眼动睡眠的持续时间和随后的非快速眼动睡眠的持续时间呈正相关。这种相关性表明，快速眼动睡眠会影响随后的非快速眼动睡眠时间，从而影响其自身的时间安排。在这里，我们开发了一个统计模型，可以准确描述小鼠自发睡眠期间先前的 REM 和随后的 NREM 睡眠持续时间之间的关系。我们应用该模型来研究 REM 睡眠与未来 NREM 睡眠质量之间的关系，并揭示决定 REM 睡眠发作时间和持续时间的因素。使用我们基于模型的方法，我们确定了影响快速眼动睡眠超昼夜调节的三个主要因素：两种类型的睡眠周期、浅度非快速眼动睡眠期（在此期间向快速眼动睡眠的转变受到抑制）以及影响随后快速眼动睡眠持续时间的倾向。
A salient feature of mammalian sleep is the alternation between rapid eye movement (REM) and non-REM (NREM) sleep. However, how these two sleep stages influence each other and thereby regulate the timing of REM sleep episodes is still largely unresolved. Here, we developed a statistical model that specifies the relationship between REM and subsequent NREM sleep to quantify how REM sleep affects the following NREM sleep duration and its electrophysiological features in mice. We show that a lognormal mixture model well describes how the preceding REM sleep duration influences the amount of NREM sleep till the next REM sleep episode. The model supports the existence of two different types of sleep cycles: Short cycles form closely interspaced sequences of REM sleep episodes, whereas during long cycles, REM sleep is first followed by an interval of NREM sleep during which transitions to REM sleep are extremely unlikely. This refractory period is characterized by low power in the theta and sigma range of the electroencephalogram (EEG), low spindle rate and frequent microarousals, and its duration proportionally increases with the preceding REM sleep duration. Using our model, we estimated the propensity for REM sleep at the transition from NREM to REM sleep and found that entering REM sleep with higher propensity resulted in longer REM sleep episodes with reduced EEG power. Compared with the light phase, the buildup of REM sleep propensity was slower during the dark phase. Our data-driven modeling approach uncovered basic principles underlying the timing and duration of REM sleep episodes in mice and provides a flexible framework to describe the ultradian regulation of REM sleep in health and disease. During sleep, the mammalian brain repeatedly alternates between two brain states: REM and NREM sleep. This ultradian oscillation constitutes a fundamental brain rhythm, the so-called sleep cycle, which is conserved across mammalian species. However, the mechanisms that generate the sleep cycle are still largely unknown. A conserved statistical feature of mammalian sleep is that the durations of REM sleep and subsequent NREM sleep are positively correlated. This correlation suggests that REM sleep impacts the amount of the following NREM sleep and thereby influences its own timing. Here, we developed a statistical model that accurately describes the relationship between the preceding REM and following NREM sleep duration during spontaneous sleep in mice. We applied this model to investigate the relationship between REM sleep and the quality of future NREM sleep, and to uncover factors that determine the timing and duration of REM sleep episodes. Using our model-based approach, we identified three major factors shaping the ultradian regulation of REM sleep: Two types of sleep cycles, a period of light NREM sleep during which transitions to REM sleep are suppressed, and a propensity that influences the subsequent REM sleep duration.
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影响因子：
11.3
作者：
Endo, T;Schwierin, B;Tobler, I
通讯作者：
Tobler, I
影响因子：
16.6
作者：
Bandarabadi M;Herrera CG;Gent TC;Bassetti C;Schindler K;Adamantidis AR
通讯作者：
Adamantidis AR
影响因子：
5.6
作者：
Bassi, Alejandro;Vivaldi, Ennio A.;Ocampo-Garces, Adrian
通讯作者：
Ocampo-Garces, Adrian
DOI：
10.1016/j.pnpbp.2010.08.023
发表时间：
2011-01-15
影响因子：
5.6
作者：
DaSilva, Jamie K.;Lei, Yanlin;Madan, Vibha;Mann, Graziella L.;Ross, Richard J.;Tejani-Butt, Shanaz;Morrison, Adrian R.
通讯作者：
Morrison, Adrian R.
影响因子：
3.7
作者：
Diedenhofen B;Musch J
通讯作者：
Musch J