Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides.

Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides.
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生物膜形成表皮葡萄球菌对苦豆子总生物碱的响应的整体转录组变化

DOI:
10.21307/pjm-2018-024
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发表时间:
2018-06-30
影响因子:
2.1
通讯作者:
Zhou XZ
Zhou XZ
中科院分区:
生物学4区
文献类型:
--
作者:
Guan CP;Luo HX;Fang HE;Zhou XZ

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观察了苦豆子总生物碱诱导表皮葡萄球菌生物被膜形成过程中转录组的变化。进一步使用生物信息学分析来比较对照和处理样品之间的差异基因表达。结果发现282个基因表达差异,其中92个上调,190个下调。这些涉及硫代谢途径的下调。结果表明,表皮葡萄球菌总生物碱对表皮葡萄球菌及其生物被膜形成的抑制作用与表皮葡萄球菌总生物碱的抑菌作用有关。苦豆素主要是通过调节S.表皮的
Transcriptome changes of biofilm-forming Staphylococcus epidermidis response to total alkaloids of Sophorea alopecuroides was observed. Bioinformatic analyses were further used to compare the differential gene expression between control and the treated samples. It was found that 282 genes were differentially expressed, with 92 up-regulated and 190 down-regulated. These involved down-regulation of the sulfur metabolism pathway. It was suggested that inhibitory effects on Staphylococcus epidermidis and its biofilm formation of the total alkaloids of S. alopecuroides was mainly due to the regulation of the sulfur metabolism pathways of S. epidermidis.
DOI: 10.1093/jac/dki217
发表时间: 2005-08-01
影响因子: 5.2
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