Pollutants and asthma: role of air toxics.
Pollutants and asthma: role of air toxics.
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DOI：
10.1289/ehp.110-1241207
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发表时间：
2002-08
影响因子：
10.4
通讯作者：
Peden DB
中科院分区：
文献类型：
--
作者：
Peden DB
哮喘是一种以间歇性支气管收缩为特征的疾病，这是由于气道对过敏性和非过敏性刺激的反应性增加所致。大多数导致住院的哮喘急性发作与病毒性上呼吸道感染有关。这种感染通常诱导气道中的T辅助细胞1型（T（H）1）应答，涉及核因子-κ B（NF-κ B）的活化。然而，最近认识到的哮喘恶化的原因是暴露于污染物，包括臭氧和颗粒物质（PM）的各种组分，包括过渡金属、柴油机废气和生物制剂如内毒素。尽管空气毒物在哮喘发病机制中的作用尚未完全研究，但PM的许多成分是哮喘的活性加重剂，也是突出的空气毒物（金属离子和有机残留物）。已观察到这些试剂活化NF-κ B。本文综述了特定空气污染物对人类气道炎症的作用，以及臭氧、PM和几种空气毒物的潜在共同反应途径。
Asthma is a disease characterized by intermittent bronchoconstriction due to increased airway reactivity to both allergic and nonallergic stimuli. Most asthma exacerbations that result in hospitalization are associated with viral upper respiratory tract infections. Such infections typically induce T-helper type 1 (T(H)1) responses in the airway, involving activation of nuclear factor-kappaB (NF-Kappa B). However, a more recently appreciated cause of asthma exacerbation is exposure to pollutants, including ozone and various components of particulate matter (PM), including transition metals, diesel exhaust, and biologicals such as endotoxin. Although the role of air toxics in asthma pathogenesis remains incompletely examined, many components of PM that are active exacerbants of asthma are also prominent air toxics (metal ions and organic residues). These agents have been observed to activate NF-Kappa B. Reviewed in this article are the actions of specific air pollutants on airway inflammation in humans and potential common response pathways for ozone, PM, and several air toxics.
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影响因子：
10.4
作者：
Dockery, DW
通讯作者：
Dockery, DW
影响因子：
14.2
作者：
DiazSanchez, D;Tsien, A;Saxon, A
通讯作者：
Saxon, A
DOI：
10.1164/ajrccm/142.3.594
发表时间：
1990-09-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
BASCOM, R;NACLERIO, RM;PROUD, D
通讯作者：
PROUD, D
DOI：
10.1152/ajplung.1996.270.5.l736
发表时间：
1996-05-01
影响因子：
4.9
作者：
Dubin, W;Martin, TR;Hasday, JD
通讯作者：
Hasday, JD
影响因子：
14.2
作者：
Eldridge, MW;Peden, DB
通讯作者：
Peden, DB