Insight into the molecular and functional diversity of cnidarian neuropeptides.
Insight into the molecular and functional diversity of cnidarian neuropeptides.
复制标题
DOI：
10.3390/ijms16022610
复制
发表时间：
2015-01-23
影响因子：
5.6
通讯作者：
Takeda N
中科院分区：
文献类型：
--
作者：
Takahashi T;Takeda N
蛇形动物是拥有神经系统的最原始的动物。水母门由水母纲(水母)、立方体水母纲(箱水母)和水母纲(水母纲、水母纲)组成，水母亚门是水母纲，安东虫纲(海葵和珊瑚)属于水母纲。神经肽有一个早期的进化起源，在蛇类中已经很丰富了。例如，我们从研究参与发育和生理过程的多肽的关键模型系统--九头蛇中，鉴定出了一系列新的神经多肽(九头蛇多肽项目)。这些多肽大多直接作用于肌肉细胞，引起收缩和松弛。一些多肽参与细胞分化和形态发生。在这篇综述中，我们描述了FMRFamide样多肽(FLP)、GLW酰胺家族多肽以及神经肽Hym-355；已经从蛇形动物等无脊椎动物身上分离出数百种Flp。GLWide家族多肽在蠕虫的肌肉收缩、变形和定居过程中起着信号分子的作用。HYM-355；FPQSFLPRG促进九头蛇神经分化。最近，GLWamide家族的多肽和Hym-355；FPQSFLPRGide被发现可以触发水生动物水母Cytaeis uchidae的卵母细胞成熟和随后的产卵。这些发现表明，这些神经肽在发育和生理过程中都很重要。
Cnidarians are the most primitive animals to possess a nervous system. This phylum is composed of the classes Scyphozoa (jellyfish), Cubozoa (box jellyfish), and Hydrozoa (e.g., Hydra, Hydractinia), which make up the subphylum Medusozoa, as well as the class Anthozoa (sea anemones and corals). Neuropeptides have an early evolutionary origin and are already abundant in cnidarians. For example, from the cnidarian Hydra, a key model system for studying the peptides involved in developmental and physiological processes, we identified a wide variety of novel neuropeptides from Hydra magnipapillata (the Hydra Peptide Project). Most of these peptides act directly on muscle cells and induce contraction and relaxation. Some peptides are involved in cell differentiation and morphogenesis. In this review, we describe FMRFamide-like peptides (FLPs), GLWamide-family peptides, and the neuropeptide Hym-355; FPQSFLPRGamide. Several hundred FLPs have been isolated from invertebrate animals such as cnidarians. GLWamide-family peptides function as signaling molecules in muscle contraction, metamorphosis, and settlement in cnidarians. Hym-355; FPQSFLPRGamide enhances neuronal differentiation in Hydra. Recently, GLWamide-family peptides and Hym-355; FPQSFLPRGamide were shown to trigger oocyte maturation and subsequent spawning in the hydrozoan jellyfish Cytaeis uchidae. These findings suggest the importance of these neuropeptides in both developmental and physiological processes.
登录
查看更多内容
DOI：
10.1007/bf00365801
发表时间：
1996-02-01
期刊：
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY
影响因子：
--
作者：
Gajewski, M;Leitz, T;Plickert, G
通讯作者：
Plickert, G
影响因子：
4.1
作者：
Darmer, D;Hauser, F;Grimmelikhuijzen, CJP
通讯作者：
Grimmelikhuijzen, CJP
影响因子：
9.2
作者：
Brogiolo, W;Stocker, H;Hafen, E
通讯作者：
Hafen, E
影响因子：
2.5
作者：
Holtmann, M;Thurm, U
通讯作者：
Thurm, U
DOI：
10.1073/pnas.83.24.9817
发表时间：
1986-12-01
影响因子：
11.1
作者：
GRIMMELIKHUIJZEN, CJP;GRAFF, D
通讯作者：
GRAFF, D