Cognitive aging in zebrafish.
Cognitive aging in zebrafish.
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DOI：
10.1371/journal.pone.0000014
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发表时间：
2006-12-20
期刊：
影响因子：
3.7
通讯作者：
Zhdanova, Irina V.
中科院分区：
文献类型：
--
作者：
Yu, Lili;Tucci, Valter;Kishi, Shuji;Zhdanova, Irina V.
认知功能中的脑相关损伤代表了日益增长的临床和社会问题。动物模型的遗传和行为表征可以提供关于内在和环境因素的关键信息，这些因素决定了一生中认知能力的退化或保留。利用图像分析技术记录了野生型、突变型和γ射线辐照斑马鱼的行为。研究了青年、中年和老年动物对空间、视觉和时间线索的条件反应。结果表明，斑马鱼衰老与认知反应的变化有关，情感上的积极和消极的经验，减少适应性协会的泛化，增加刻板和减少探索行为和改变时间夹带。与野生型同胞相比，胆碱能传递的基因上调减弱了中年achesb 55/+突变体的认知能力下降。相反，γ射线照射的遗传毒性应激加速了幼斑马鱼认知障碍的发生。这些发现将允许使用在斑马鱼领域积累的强大的分子生物学资源来解决认知衰老的机制，并促进寻找可能减轻年龄相关的认知下降的治疗策略。
Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and environmental factors that determine the deterioration or preservation of cognitive abilities throughout life. Behavior of wild-type, mutant and gamma-irradiated zebrafish (Danio rerio) was documented using image-analysis technique. Conditioned responses to spatial, visual and temporal cues were investigated in young, middle-aged and old animals. The results demonstrate that zebrafish aging is associated with changes in cognitive responses to emotionally positive and negative experiences, reduced generalization of adaptive associations, increased stereotypic and reduced exploratory behavior and altered temporal entrainment. Genetic upregulation of cholinergic transmission attenuates cognitive decline in middle-aged achesb55/+ mutants, compared to wild-type siblings. In contrast, the genotoxic stress of gamma-irradiation accelerates the onset of cognitive impairment in young zebrafish. These findings would allow the use of powerful molecular biological resources accumulated in the zebrafish field to address the mechanisms of cognitive senescence, and promote the search for therapeutic strategies which may attenuate age-related cognitive decline.
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