Pontine Waves Accompanied by Short Hippocampal Sharp Wave-Ripples During Non-rapid Eye Movement Sleep.
Pontine Waves Accompanied by Short Hippocampal Sharp Wave-Ripples During Non-rapid Eye Movement Sleep.
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脑桥-膝状体-枕（ponto-geniculo-ocipital）或脑桥（P）波长期以来被认为是快速眼动（REM）睡眠的电生理特征。然而，P波不仅可以在REM睡眠期间观察到，还可以在非REM（NREM）睡眠期间观察到。最近的研究发现，在NREM睡眠期间，P波与海马尖波波纹（SWRs）功能耦合。然而，目前还不清楚在何种程度上，P波在NREM睡眠期间共享他们的特点与P波在REM睡眠期间，以及如何功能耦合到P波调制SWR。在这里，我们通过在两种性别的小鼠中进行多种类型的电生理记录和纤维光度测定来解决这些问题。NREM睡眠期间的P波与REM睡眠期间的P波在短时间（~100毫秒）内共享其波形形状和局部神经系综动力学。然而，中桥脑胆碱能神经元的动力学在较长（~10秒）的时间尺度上是不同的：尽管P波伴随着胆碱能瞬变，但在NREM睡眠期间，胆碱能神经元的张力在P波发生之前逐渐降低。虽然P波在REM睡眠期间与海马θ节律耦合，但NREM睡眠期间的P波伴随着海马波纹功率的快速减少。与P波耦合的SWR是短暂的，并且P波之后海马神经放电也减少。这些结果表明，P波是协调的睡眠相关活动的一部分，在功能上耦合与海马合奏的状态依赖性的方式。
Ponto-geniculo-occipital or pontine (P) waves have long been recognized as an electrophysiological signature of rapid eye movement (REM) sleep. However, P-waves can be observed not just during REM sleep, but also during non-REM (NREM) sleep. Recent studies have uncovered that P-waves are functionally coupled with hippocampal sharp wave ripples (SWRs) during NREM sleep. However, it remains unclear to what extent P-waves during NREM sleep share their characteristics with P-waves during REM sleep and how the functional coupling to P-waves modulates SWRs. Here, we address these issues by performing multiple types of electrophysiological recordings and fiber photometry in both sexes of mice. P-waves during NREM sleep share their waveform shapes and local neural ensemble dynamics at a short (~100 milliseconds) timescale with their REM sleep counterparts. However, the dynamics of mesopontine cholinergic neurons are distinct at a longer (~10 seconds) timescale: although P-waves are accompanied by cholinergic transients, the cholinergic tone gradually reduces before P-wave genesis during NREM sleep. While P-waves are coupled to hippocampal theta rhythms during REM sleep, P-waves during NREM sleep are accompanied by a rapid reduction in hippocampal ripple power. SWRs coupled with P-waves are short-lived and hippocampal neural firing is also reduced after P-waves. These results demonstrate that P-waves are part of coordinated sleep-related activity by functionally coupling with hippocampal ensembles in a state-dependent manner.
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