Distinct Temporal Coordination of Spontaneous Population Activity between Basal Forebrain and Auditory Cortex.
Distinct Temporal Coordination of Spontaneous Population Activity between Basal Forebrain and Auditory Cortex.
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DOI：
10.3389/fncir.2017.00064
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发表时间：
2017
影响因子：
3.5
通讯作者：
Sakata S
中科院分区：
文献类型：
--
作者：
Yague JG;Tsunematsu T;Sakata S
基底前脑（BF）长期以来被认为与注意力、学习和记忆有关，最近的研究已经建立了人工基底前脑激活和唤醒之间的因果关系。然而，BF中的神经系动力学仍然不清楚。在此，我们记录了脑前部神经群的活动，并将其与麻醉和非麻醉条件下同时记录的皮层神经群进行了比较，研究了小鼠脑前部和听觉皮层（AC）自发神经群活动结构的差异。交流神经元群表现出倾斜的尖峰率分布，较高比例的短（≤80 ms）尖峰间隔（ISIs）和丰富的跨频率有节奏的放电。虽然BF中自发放电率的分布也有偏差，但短ISIs的比例可以用泊松模型在短时间尺度（≤20 ms）下解释，与交流细胞相比，尖峰计数的相关性较低，光遗传鉴定的胆碱能细胞对显示出异常高的相关性。此外，一小部分BF神经元表现出跨频率的峰场携带：一部分BF神经元以慢频率（≤6 Hz）有节奏地放电，与持续的场电位相偏好不同，与交流群体一致的相偏好相反。与其他节律性BF细胞对相比，这些慢节律性BF细胞的放电有更大程度的相关性。总的来说，人口活动结构的根本区别在于它们的时间协调，特别是它们的行动时间尺度。这些结果表明BF神经元缓慢调节下游种群，而皮层回路在多个时间尺度上传递信号。因此，BF中神经集成动力学的表征提供了对大脑状态调节的神经机制的进一步了解。
The basal forebrain (BF) has long been implicated in attention, learning and memory, and recent studies have established a causal relationship between artificial BF activation and arousal. However, neural ensemble dynamics in the BF still remains unclear. Here, recording neural population activity in the BF and comparing it with simultaneously recorded cortical population under both anesthetized and unanesthetized conditions, we investigate the difference in the structure of spontaneous population activity between the BF and the auditory cortex (AC) in mice. The AC neuronal population show a skewed spike rate distribution, a higher proportion of short (≤80 ms) inter-spike intervals (ISIs) and a rich repertoire of rhythmic firing across frequencies. Although the distribution of spontaneous firing rate in the BF is also skewed, a proportion of short ISIs can be explained by a Poisson model at short time scales (≤20 ms) and spike count correlations are lower compared to AC cells, with optogenetically identified cholinergic cell pairs showing exceptionally higher correlations. Furthermore, a smaller fraction of BF neurons shows spike-field entrainment across frequencies: a subset of BF neurons fire rhythmically at slow (≤6 Hz) frequencies, with varied phase preferences to ongoing field potentials, in contrast to a consistent phase preference of AC populations. Firing of these slow rhythmic BF cells is correlated to a greater degree than other rhythmic BF cell pairs. Overall, the fundamental difference in the structure of population activity between the AC and BF is their temporal coordination, in particular their operational timescales. These results suggest that BF neurons slowly modulate downstream populations whereas cortical circuits transmit signals on multiple timescales. Thus, the characterization of the neural ensemble dynamics in the BF provides further insight into the neural mechanisms, by which brain states are regulated.
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影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
3.5
作者：
Harrison TC;Pinto L;Brock JR;Dan Y
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Dan Y
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作者：
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