Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson's disease.
Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson's disease.
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DOI：
10.1038/s41531-021-00229-z
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发表时间：
2021-09-28
期刊：
影响因子：
--
通讯作者：
Marceglia S
中科院分区：
文献类型：
--
作者：
Bocci T;Prenassi M;Arlotti M;Cogiamanian FM;Borellini L;Moro E;Lozano AM;Volkmann J;Barbieri S;Priori A;Marceglia S
本研究比较了常规脑深部刺激（cDBS）和闭环适应性脑深部刺激（aDBS）对帕金森病患者运动症状的影响。aDBS刺激由丘脑下核电极直接记录的局部场电位的β带（12 ~ 35hz）功率控制。8名受试者在常规左旋多巴摄入和正常日常活动中进行两次8小时刺激（第一天，cDBS；第二天，aDBS）。统一帕金森病评定量表（UPDRS）第三部分评分、运动障碍的Rush量表和每秒传递到组织的总电能（teed）在aDBS过程中显著降低(相对UPDRS平均值，cDBS: 0.46±0.05,aDBS: 0.33±0.04,p = 0.015； UPDRS第三部分刚性子集平均值，cDBS: 2.9143±0.6551,aDBS: 2.1429±0.5010,p = 0.034； UPDRS第三部分标准差cDBS: 2.95, aDBS: 2.68, p = 0.047；Rush量表，cDBS 2.79±0.39 vs aDBS 1.57±0.23,p = 0.037；cDBS TEEDs平均值：28.75±3.36µj s−1，aDBS TEEDs平均值：16.47±3.33,p = 0.032。在运动表现和患者的TEED方面，这项工作进一步支持了与cDBS相比，aDBS刺激在日常会话中的安全性和有效性。
This study compares the effects on motor symptoms between conventional deep brain stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with Parkinson’s Disease. The aDBS stimulation is controlled by the power in the beta band (12–35 Hz) of local field potentials recorded directly by subthalamic nucleus electrodes. Eight subjects were assessed in two 8-h stimulation sessions (first day, cDBS; second day, aDBS) with regular levodopa intake and during normal daily activities. The Unified Parkinson’s Disease Rating Scale (UPDRS) part III scores, the Rush scale for dyskinesias, and the total electrical energy delivered to the tissues per second (TEEDs) were significantly lower in the aDBS session (relative UPDRS mean, cDBS: 0.46 ± 0.05, aDBS: 0.33 ± 0.04, p = 0.015; UPDRS part III rigidity subset mean, cDBS: 2.9143 ± 0.6551 and aDBS: 2.1429 ± 0.5010, p = 0.034; UPDRS part III standard deviation cDBS: 2.95, aDBS: 2.68; p = 0.047; Rush scale, cDBS 2.79 ± 0.39 versus aDBS 1.57 ± 0.23, p = 0.037; cDBS TEEDs mean: 28.75 ± 3.36 µj s−1, aDBS TEEDs mean: 16.47 ± 3.33, p = 0.032 Wilcoxon’s sign rank test). This work further supports the safety and effectiveness of aDBS stimulation compared to cDBS in a daily session, both in terms of motor performance and TEED to the patient.
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影响因子：
8.6
作者：
Neumann, Wolf-Julian;Degen, Katharina;Schneider, Gerd-Helge;Bruecke, Christof;Huebl, Julius;Brown, Peter;Kuehn, Andrea A.
通讯作者：
Kuehn, Andrea A.
晚期帕金森病的自适应深脑刺激。
影响因子：
11.2
作者：
Little, Simon;Pogosyan, Alex;Neal, Spencer;Zavala, Baltazar;Zrinzo, Ludvic;Hariz, Marwan;Foltynie, Thomas;Limousin, Patricia;Ashkan, Keyoumars;FitzGerald, James;Green, Alexander L.;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
5.3
作者：
Alavi, Mahan;Dostrovsky, Jonathan O.;Hutchison, William D.
通讯作者：
Hutchison, William D.
影响因子：
7.7
作者：
Tan, Huiling;Debarros, Jean;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
158.5
作者：
Krack, P;Batir, A;Pollak, P
通讯作者：
Pollak, P