More time awake after sleep onset is linked to reduced ventral striatum response to rewards in youth with anxiety.
More time awake after sleep onset is linked to reduced ventral striatum response to rewards in youth with anxiety.
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入睡后清醒的时间越长，与患有焦虑症的青少年腹侧纹状体对奖励的反应减少有关。
DOI：
10.1111/jcpp.13669
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
McMakin,DanaL
中科院分区：
文献类型：
--
作者：
Sollenberger,NathanA;Sequeira,Stefanie;Forbes,ErikaE;Siegle,GregJ;Silk,JenniferS;Ladouceur,CecileD;Ryan,NealD;Dahl,RonaldE;Mattfeld,AaronT;McMakin,DanaL
背景：睡眠不良和焦虑障碍在青少年中是高度共病的，两者都预示着腹侧纹状体（VS）对奖励的反应改变，这可能会影响心理健康风险。对比证据表明，先前报道的睡眠健康和VS反应之间的负相关可能在焦虑的青少年中更强或更弱，分别表明对输赢信息的敏感性或迟钝的奖励处理。我们横断面研究了睡眠在焦虑青少年VS对奖励的反应中的作用，与无精神病诊断比较（ND）组相比。我们期望在VS对奖励的反应上有一组睡眠交互作用，但没有假设方向性。方法作为预处理电池的一部分，74名焦虑青少年和31名ND青少年（年龄9-14岁；n= 55名女性）在fMRI期间完成了金钱奖励任务。在相同的预处理窗口期间，收集了5天的活动记录仪和睡眠日记，参与者及其父母分别报告了参与者的总睡眠问题。我们分别通过活动记录仪、日记和问卷调查的三种混合线性模型，研究了组*睡眠对VS对金钱奖励和损失的反应的相互作用。结果各模型均显示组*睡眠对VS奖励反应的交互作用。活动描记和睡眠开始后醒来的日记估计时间预测焦虑青少年的VS反应降低，而非ND青少年。家长报告的睡眠问题与对照组有相似的相互作用，但单纯的斜率不显著。结论睡眠后醒来与焦虑青少年的奖励反应迟钝有关。这些数据表明，睡眠可能会导致焦虑青少年的奖赏功能紊乱和奖赏相关的精神病理（如抑郁症）。
BackgroundPoor sleep and anxiety disorders are highly comorbid in youth, and each predicts altered ventral striatum (VS) response to rewards, which may impact mental health risk. Contrasting evidence suggests previously reported negative associations between sleep health and VS response may be stronger or weaker in youth with anxiety, indicating sensitivity to win/loss information or blunted reward processing, respectively. We cross‐sectionally examined the role of sleep in VS response to rewards among youth with anxiety versus a no‐psychiatric‐diagnosis comparison (ND) group. We expected a group*sleep interaction on VS response to rewards but did not hypothesize directionality.MethodsAs part of the pretreatment battery for a randomized clinical trial, 74 youth with anxiety and 31 ND youth (ages 9–14 years;n= 55 female) completed a monetary reward task during fMRI. During the same pretreatment window, actigraphy and diary‐estimated sleep were collected over 5 days, and participants and their parents each reported participants' total sleep problems. We examined group*sleep interactions on VS response to monetary rewards versus losses via three mixed linear models corresponding to actigraphy, diary, and questionnaires, respectively.ResultsEach model indicated group*sleep interactions on VS response to rewards. Actigraphy and diary‐estimated time awake after sleep onset predicted reduced VS response in youth with anxiety but not ND youth. Parent‐reported sleep problems similarly interacted with group, but simple slopes were nonsignificant.ConclusionsWake after sleep onset was associated with blunted reward response in youth with anxiety. These data suggest a potential pathway through which sleep could contribute to perturbed reward function and reward‐related psychopathology (e.g., depression) in youth with anxiety.
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DOI：
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DOI：
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发表时间：
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The American journal of psychiatry
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